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Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys

Lipids are essential components of the brain. Here, we conducted a comprehensive mass spectrometry-based analysis of lipidome composition in the prefrontal cortex of 40 humans, 40 chimpanzees, and 40 rhesus monkeys over postnatal development and adulthood. Of the 11,772 quantified lipid peaks, 7,589...

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Autores principales: Li, Qian, Bozek, Katarzyna, Xu, Chuan, Guo, Yanan, Sun, Jing, Pääbo, Svante, Sherwood, Chet C., Hof, Patrick R., Ely, John J., Li, Yan, Willmitzer, Lothar, Giavalisco, Patrick, Khaitovich, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400384/
https://www.ncbi.nlm.nih.gov/pubmed/28158622
http://dx.doi.org/10.1093/molbev/msx065
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author Li, Qian
Bozek, Katarzyna
Xu, Chuan
Guo, Yanan
Sun, Jing
Pääbo, Svante
Sherwood, Chet C.
Hof, Patrick R.
Ely, John J.
Li, Yan
Willmitzer, Lothar
Giavalisco, Patrick
Khaitovich, Philipp
author_facet Li, Qian
Bozek, Katarzyna
Xu, Chuan
Guo, Yanan
Sun, Jing
Pääbo, Svante
Sherwood, Chet C.
Hof, Patrick R.
Ely, John J.
Li, Yan
Willmitzer, Lothar
Giavalisco, Patrick
Khaitovich, Philipp
author_sort Li, Qian
collection PubMed
description Lipids are essential components of the brain. Here, we conducted a comprehensive mass spectrometry-based analysis of lipidome composition in the prefrontal cortex of 40 humans, 40 chimpanzees, and 40 rhesus monkeys over postnatal development and adulthood. Of the 11,772 quantified lipid peaks, 7,589 change significantly along the lifespan. More than 60% of these changes occur prior to adulthood, with less than a quarter associated with myelination progression. Evolutionarily, 36% of the age-dependent lipids exhibit concentration profiles distinct to one of the three species; 488 (18%) of them were unique to humans. In both humans and chimpanzees, the greatest extent of species-specific differences occurs in early development. Human-specific lipidome differences, however, persist over most of the lifespan and reach their peak from 20 to 35 years of age, when compared with chimpanzee-specific ones.
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spelling pubmed-54003842017-04-28 Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys Li, Qian Bozek, Katarzyna Xu, Chuan Guo, Yanan Sun, Jing Pääbo, Svante Sherwood, Chet C. Hof, Patrick R. Ely, John J. Li, Yan Willmitzer, Lothar Giavalisco, Patrick Khaitovich, Philipp Mol Biol Evol Discoveries Lipids are essential components of the brain. Here, we conducted a comprehensive mass spectrometry-based analysis of lipidome composition in the prefrontal cortex of 40 humans, 40 chimpanzees, and 40 rhesus monkeys over postnatal development and adulthood. Of the 11,772 quantified lipid peaks, 7,589 change significantly along the lifespan. More than 60% of these changes occur prior to adulthood, with less than a quarter associated with myelination progression. Evolutionarily, 36% of the age-dependent lipids exhibit concentration profiles distinct to one of the three species; 488 (18%) of them were unique to humans. In both humans and chimpanzees, the greatest extent of species-specific differences occurs in early development. Human-specific lipidome differences, however, persist over most of the lifespan and reach their peak from 20 to 35 years of age, when compared with chimpanzee-specific ones. Oxford University Press 2017-05 2017-01-31 /pmc/articles/PMC5400384/ /pubmed/28158622 http://dx.doi.org/10.1093/molbev/msx065 Text en © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Discoveries
Li, Qian
Bozek, Katarzyna
Xu, Chuan
Guo, Yanan
Sun, Jing
Pääbo, Svante
Sherwood, Chet C.
Hof, Patrick R.
Ely, John J.
Li, Yan
Willmitzer, Lothar
Giavalisco, Patrick
Khaitovich, Philipp
Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys
title Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys
title_full Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys
title_fullStr Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys
title_full_unstemmed Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys
title_short Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys
title_sort changes in lipidome composition during brain development in humans, chimpanzees, and macaque monkeys
topic Discoveries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400384/
https://www.ncbi.nlm.nih.gov/pubmed/28158622
http://dx.doi.org/10.1093/molbev/msx065
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