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Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin

If the fitness effects of amino acid mutations are conditional on genetic background, then mutations can have different effects depending on the sequential order in which they occur during evolutionary transitions in protein function. A key question concerns the fraction of possible mutational pathw...

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Detalles Bibliográficos
Autores principales:	Kumar, Amit, Natarajan, Chandrasekhar, Moriyama, Hideaki, Witt, Christopher C., Weber, Roy E., Fago, Angela, Storz, Jay F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Discoveries
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400398/ https://www.ncbi.nlm.nih.gov/pubmed/28201714 http://dx.doi.org/10.1093/molbev/msx085

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