ADDA: a domain database with global coverage of the protein universe

We used the Automatic Domain Decomposition Algorithm (ADDA) to generate a database of protein domain families with complete coverage of all protein sequences. Sequences are split into domains and domains are grouped into protein domain families in a completely automated process. The current database...

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Detalles Bibliográficos
Autores principales: Heger, Andreas, Wilton, Christopher Andrew, Sivakumar, Ashwin, Holm, Liisa
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC540050/
https://www.ncbi.nlm.nih.gov/pubmed/15608174
http://dx.doi.org/10.1093/nar/gki096
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author Heger, Andreas
Wilton, Christopher Andrew
Sivakumar, Ashwin
Holm, Liisa
author_facet Heger, Andreas
Wilton, Christopher Andrew
Sivakumar, Ashwin
Holm, Liisa
author_sort Heger, Andreas
collection PubMed
description We used the Automatic Domain Decomposition Algorithm (ADDA) to generate a database of protein domain families with complete coverage of all protein sequences. Sequences are split into domains and domains are grouped into protein domain families in a completely automated process. The current database contains domains for more than 1.5 million sequences in more than 40 000 domain families. In particular, there are 3828 novel domain families that do not overlap with the curated domain databases Pfam, SCOP and InterPro. The data are freely available for downloading and querying via a web interface (http://ekhidna.biocenter.helsinki.fi:9801/sqgraph/pairsdb).
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spelling pubmed-5400502005-01-04 ADDA: a domain database with global coverage of the protein universe Heger, Andreas Wilton, Christopher Andrew Sivakumar, Ashwin Holm, Liisa Nucleic Acids Res Articles We used the Automatic Domain Decomposition Algorithm (ADDA) to generate a database of protein domain families with complete coverage of all protein sequences. Sequences are split into domains and domains are grouped into protein domain families in a completely automated process. The current database contains domains for more than 1.5 million sequences in more than 40 000 domain families. In particular, there are 3828 novel domain families that do not overlap with the curated domain databases Pfam, SCOP and InterPro. The data are freely available for downloading and querying via a web interface (http://ekhidna.biocenter.helsinki.fi:9801/sqgraph/pairsdb). Oxford University Press 2005-01-01 2004-12-17 /pmc/articles/PMC540050/ /pubmed/15608174 http://dx.doi.org/10.1093/nar/gki096 Text en Copyright © 2005 Oxford University Press
spellingShingle Articles
Heger, Andreas
Wilton, Christopher Andrew
Sivakumar, Ashwin
Holm, Liisa
ADDA: a domain database with global coverage of the protein universe
title ADDA: a domain database with global coverage of the protein universe
title_full ADDA: a domain database with global coverage of the protein universe
title_fullStr ADDA: a domain database with global coverage of the protein universe
title_full_unstemmed ADDA: a domain database with global coverage of the protein universe
title_short ADDA: a domain database with global coverage of the protein universe
title_sort adda: a domain database with global coverage of the protein universe
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC540050/
https://www.ncbi.nlm.nih.gov/pubmed/15608174
http://dx.doi.org/10.1093/nar/gki096
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