Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD

TEAD (TEA/ATTS domain) transcription factors are the most distal effectors of the Hippo pathway. YAP (Yes-associated protein) is a coactivator protein which, upon binding to TEAD proteins, stimulates their transcriptional activity. Since the Hippo pathway is deregulated in various cancers, designing...

Descripción completa

Detalles Bibliográficos
Autores principales: Mesrouze, Yannick, Bokhovchuk, Fedir, Meyerhofer, Marco, Fontana, Patrizia, Zimmermann, Catherine, Martin, Typhaine, Delaunay, Clara, Erdmann, Dirk, Schmelzle, Tobias, Chène, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400505/
https://www.ncbi.nlm.nih.gov/pubmed/28430104
http://dx.doi.org/10.7554/eLife.25068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400505/
https://www.ncbi.nlm.nih.gov/pubmed/28430104
http://dx.doi.org/10.7554/eLife.25068

Ejemplares similares