Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

Chromosome instability (CIN) is deleterious to normal cells because of the burden of aneuploidy. However, most human solid tumors have an abnormal karyotype implying that gain and loss of chromosomes by cancer cells confers a selective advantage. CIN can be induced in the mouse by inactivating the s...

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Detalles Bibliográficos
Autores principales: Foijer, Floris, Albacker, Lee A, Bakker, Bjorn, Spierings, Diana C, Yue, Ying, Xie, Stephanie Z, Davis, Stephanie, Lutum-Jehle, Annegret, Takemoto, Darin, Hare, Brian, Furey, Brinley, Bronson, Roderick T, Lansdorp, Peter M, Bradley, Allan, Sorger, Peter K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400506/
https://www.ncbi.nlm.nih.gov/pubmed/28318489
http://dx.doi.org/10.7554/eLife.20873

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