The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration

Hesperetin has been suggested to be involved in bone strength. We aimed to investigate the effects of hesperetin on the osteogenic differentiation of human mesenchymal stem cells and its related mechanisms. We showed that hesperetin promoted osteogenic differentiation of human mesenchymal stem cells...

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Autores principales: Xue, Deting, Chen, Erman, Zhang, Wei, Gao, Xiang, Wang, Shengdong, Zheng, Qiang, Pan, Zhijun, Li, Hang, Liu, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400563/
https://www.ncbi.nlm.nih.gov/pubmed/28423500
http://dx.doi.org/10.18632/oncotarget.15473
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author Xue, Deting
Chen, Erman
Zhang, Wei
Gao, Xiang
Wang, Shengdong
Zheng, Qiang
Pan, Zhijun
Li, Hang
Liu, Ling
author_facet Xue, Deting
Chen, Erman
Zhang, Wei
Gao, Xiang
Wang, Shengdong
Zheng, Qiang
Pan, Zhijun
Li, Hang
Liu, Ling
author_sort Xue, Deting
collection PubMed
description Hesperetin has been suggested to be involved in bone strength. We aimed to investigate the effects of hesperetin on the osteogenic differentiation of human mesenchymal stem cells and its related mechanisms. We showed that hesperetin promoted osteogenic differentiation of human mesenchymal stem cells in vitro. It potentially exerts its effects via the ERK and Smad signaling pathways. Using a rat osteotomy model, we showed that human mesenchymal stem cells combined with a hesperetin/gelatin sponge scaffold resulted in accelerated fracture healing in vivo. Due to the low cost of hesperetin, it could be used as a growth factor for bone tissue engineering or surgical fracture treatment.
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spelling pubmed-54005632017-05-03 The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration Xue, Deting Chen, Erman Zhang, Wei Gao, Xiang Wang, Shengdong Zheng, Qiang Pan, Zhijun Li, Hang Liu, Ling Oncotarget Research Paper Hesperetin has been suggested to be involved in bone strength. We aimed to investigate the effects of hesperetin on the osteogenic differentiation of human mesenchymal stem cells and its related mechanisms. We showed that hesperetin promoted osteogenic differentiation of human mesenchymal stem cells in vitro. It potentially exerts its effects via the ERK and Smad signaling pathways. Using a rat osteotomy model, we showed that human mesenchymal stem cells combined with a hesperetin/gelatin sponge scaffold resulted in accelerated fracture healing in vivo. Due to the low cost of hesperetin, it could be used as a growth factor for bone tissue engineering or surgical fracture treatment. Impact Journals LLC 2017-02-18 /pmc/articles/PMC5400563/ /pubmed/28423500 http://dx.doi.org/10.18632/oncotarget.15473 Text en Copyright: © 2017 Xue et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Xue, Deting
Chen, Erman
Zhang, Wei
Gao, Xiang
Wang, Shengdong
Zheng, Qiang
Pan, Zhijun
Li, Hang
Liu, Ling
The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration
title The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration
title_full The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration
title_fullStr The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration
title_full_unstemmed The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration
title_short The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration
title_sort role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400563/
https://www.ncbi.nlm.nih.gov/pubmed/28423500
http://dx.doi.org/10.18632/oncotarget.15473
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