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Long non-coding RNA HULC as a potential prognostic biomarker in human cancers: a meta-analysis
Since the long non-coding RNA HULC (Highly Upregulated in Liver Cancer) is dysregulated in many cancers, we performed a meta-analysis to determine its prognostic potential in malignant tumors. We searched electronic databases, including PubMed, Medline, OVID, Cochrane Library and Web of Science from...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400593/ https://www.ncbi.nlm.nih.gov/pubmed/28199963 http://dx.doi.org/10.18632/oncotarget.15247 |
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author | Fan, Yang-Hua Wu, Miao-Jing Jiang, Yuan Ye, Minhua Lu, Shi-Gang Wu, Lei Zhu, Xin-Gen |
author_facet | Fan, Yang-Hua Wu, Miao-Jing Jiang, Yuan Ye, Minhua Lu, Shi-Gang Wu, Lei Zhu, Xin-Gen |
author_sort | Fan, Yang-Hua |
collection | PubMed |
description | Since the long non-coding RNA HULC (Highly Upregulated in Liver Cancer) is dysregulated in many cancers, we performed a meta-analysis to determine its prognostic potential in malignant tumors. We searched electronic databases, including PubMed, Medline, OVID, Cochrane Library and Web of Science from inception until August 14, 2016 and identified seven studies with 730 cancer patients for the meta-analysis. We analyzed the hazard ratios (HRs) and 95% confidence intervals (CIs) to determine the relationship between HULC expression and overall survival (OS). We also using RevMan5.3 software to calculate odds ratio (ORs) to assess the association between HULC expression and pathological parameters, including lymph node metastasis (LNM), distant metastasis (DM) and the tumor stage. Our analysis showed that higher HULC expression was associated with OS (HR= 0.50, 95% CI: 0.35–0.70, P <0.00001), LNM (OR=0.20, 95 % CI 0.06–0.64), DM (OR=0.27, 95% CI: 0.13–0.54) and the tumor stage (OR=0.39, 95 % CI 0.25–0.64). These meta-analysis data demonstrate that higher HULC expression can be a useful prognostic biomarker in human cancers. |
format | Online Article Text |
id | pubmed-5400593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-54005932017-05-03 Long non-coding RNA HULC as a potential prognostic biomarker in human cancers: a meta-analysis Fan, Yang-Hua Wu, Miao-Jing Jiang, Yuan Ye, Minhua Lu, Shi-Gang Wu, Lei Zhu, Xin-Gen Oncotarget Research Paper Since the long non-coding RNA HULC (Highly Upregulated in Liver Cancer) is dysregulated in many cancers, we performed a meta-analysis to determine its prognostic potential in malignant tumors. We searched electronic databases, including PubMed, Medline, OVID, Cochrane Library and Web of Science from inception until August 14, 2016 and identified seven studies with 730 cancer patients for the meta-analysis. We analyzed the hazard ratios (HRs) and 95% confidence intervals (CIs) to determine the relationship between HULC expression and overall survival (OS). We also using RevMan5.3 software to calculate odds ratio (ORs) to assess the association between HULC expression and pathological parameters, including lymph node metastasis (LNM), distant metastasis (DM) and the tumor stage. Our analysis showed that higher HULC expression was associated with OS (HR= 0.50, 95% CI: 0.35–0.70, P <0.00001), LNM (OR=0.20, 95 % CI 0.06–0.64), DM (OR=0.27, 95% CI: 0.13–0.54) and the tumor stage (OR=0.39, 95 % CI 0.25–0.64). These meta-analysis data demonstrate that higher HULC expression can be a useful prognostic biomarker in human cancers. Impact Journals LLC 2017-02-10 /pmc/articles/PMC5400593/ /pubmed/28199963 http://dx.doi.org/10.18632/oncotarget.15247 Text en Copyright: © 2017 Fan et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Fan, Yang-Hua Wu, Miao-Jing Jiang, Yuan Ye, Minhua Lu, Shi-Gang Wu, Lei Zhu, Xin-Gen Long non-coding RNA HULC as a potential prognostic biomarker in human cancers: a meta-analysis |
title | Long non-coding RNA HULC as a potential prognostic biomarker in human cancers: a meta-analysis |
title_full | Long non-coding RNA HULC as a potential prognostic biomarker in human cancers: a meta-analysis |
title_fullStr | Long non-coding RNA HULC as a potential prognostic biomarker in human cancers: a meta-analysis |
title_full_unstemmed | Long non-coding RNA HULC as a potential prognostic biomarker in human cancers: a meta-analysis |
title_short | Long non-coding RNA HULC as a potential prognostic biomarker in human cancers: a meta-analysis |
title_sort | long non-coding rna hulc as a potential prognostic biomarker in human cancers: a meta-analysis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400593/ https://www.ncbi.nlm.nih.gov/pubmed/28199963 http://dx.doi.org/10.18632/oncotarget.15247 |
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