Critically short telomeres and toxicity of chemotherapy in early breast cancer

Cumulative toxicity from weekly paclitaxel (myalgia, peripheral neuropathy, fatigue) compromises long-term administration. Preclinical data suggest that the burden of critically short telomeres (< 3 kilobases, CSTs), but not average telomere length by itself, accounts for limited tissue renewal a...

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Detalles Bibliográficos
Autores principales: Quintela-Fandino, Miguel, Soberon, Nora, Lluch, Ana, Manso, Luis, Calvo, Isabel, Cortes, Javier, Moreno-Antón, Fernando, Gil-Gil, Miguel, Martinez-Jánez, Noelia, Gonzalez-Martin, Antonio, Adrover, Encarna, de Andres, Raquel, Viñas, Gemma, Llombart-Cussac, Antonio, Alba, Emilio, Mouron, Silvana, Guerra, Juan, Bermejo, Begoña, Zamora, Esther, García-Saenz, Jose Angel, Simon, Sonia Pernas, Carrasco, Eva, Escudero, María José, Campo, Ruth, Colomer, Ramón, Blasco, Maria A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400599/
https://www.ncbi.nlm.nih.gov/pubmed/28423524
http://dx.doi.org/10.18632/oncotarget.15592

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