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Patterns of failure and clinical outcomes of definitive radiotherapy for cervical esophageal cancer
PURPOSE: Because of the scarcity of cervical esophageal cancer (CEC), data for this disease entity is limited. We aim to evaluate the outcomes, prognostic factors and failure patterns of CEC treated by contemporary radiotherapy (RT). METHODS: We retrospectively analyzed 86 CEC patients consecutively...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400628/ https://www.ncbi.nlm.nih.gov/pubmed/28423530 http://dx.doi.org/10.18632/oncotarget.15665 |
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author | Zhao, Lina Zhou, Yongchun Mu, Yunfeng Chai, Guangjin Xiao, Feng Tan, Lina Lin, Steven H. Shi, Mei |
author_facet | Zhao, Lina Zhou, Yongchun Mu, Yunfeng Chai, Guangjin Xiao, Feng Tan, Lina Lin, Steven H. Shi, Mei |
author_sort | Zhao, Lina |
collection | PubMed |
description | PURPOSE: Because of the scarcity of cervical esophageal cancer (CEC), data for this disease entity is limited. We aim to evaluate the outcomes, prognostic factors and failure patterns of CEC treated by contemporary radiotherapy (RT). METHODS: We retrospectively analyzed 86 CEC patients consecutively treated between 2007 and 2015 by definitive RT with or without concurrent chemotherapy. RT was mainly delivered with Intensity Modulated Irradiation Therapy (IMRT) or Volumetric-Modulated Arc Therapy (VMAT). Statistical analyses were performed on survival, prognostic factors and failure patterns. RESULTS: The median follow-up time was 19.4 months. The 3-year overall survival (OS), local regional failure free survival (LRFFS), distant metastatic free survival (DMFS), and progression free survival (PFS) were 53.6%, 57.9%, 81.5% and 41.5%, respectively. Independent predictors for poorer OS were N stage, hoarseness and recurrent laryngeal nerve lymph node (RLN) involvement, and predictors for LRFFS were N stage and EQD2 (equivalent dose in 2 Gy fraction) to gross tumor volume (GTV), with ≥ 66Gy achieving local control of 94.7%. Patients receiving elective nodal irradiation (ENI) had better nodal regional control than those receiving involved field irradiation (IFI). 31 (36%) patients had treatment failure and 15 (17.4%), 8 (9.3%) and 14 (16.2%) patients had local, regional, and distant failure, respectively. 86.7% (13/15) local failures were within GTV, and supraclavicular region (62.5%, 5/8) was the most common regional failure site. No severe toxicities were observed. CONCLUSIONS: Our results seem to indicate that good locoregional control might be achieved for CEC with adequate radiation dose and treatment planning approaches. |
format | Online Article Text |
id | pubmed-5400628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-54006282017-05-03 Patterns of failure and clinical outcomes of definitive radiotherapy for cervical esophageal cancer Zhao, Lina Zhou, Yongchun Mu, Yunfeng Chai, Guangjin Xiao, Feng Tan, Lina Lin, Steven H. Shi, Mei Oncotarget Research Paper PURPOSE: Because of the scarcity of cervical esophageal cancer (CEC), data for this disease entity is limited. We aim to evaluate the outcomes, prognostic factors and failure patterns of CEC treated by contemporary radiotherapy (RT). METHODS: We retrospectively analyzed 86 CEC patients consecutively treated between 2007 and 2015 by definitive RT with or without concurrent chemotherapy. RT was mainly delivered with Intensity Modulated Irradiation Therapy (IMRT) or Volumetric-Modulated Arc Therapy (VMAT). Statistical analyses were performed on survival, prognostic factors and failure patterns. RESULTS: The median follow-up time was 19.4 months. The 3-year overall survival (OS), local regional failure free survival (LRFFS), distant metastatic free survival (DMFS), and progression free survival (PFS) were 53.6%, 57.9%, 81.5% and 41.5%, respectively. Independent predictors for poorer OS were N stage, hoarseness and recurrent laryngeal nerve lymph node (RLN) involvement, and predictors for LRFFS were N stage and EQD2 (equivalent dose in 2 Gy fraction) to gross tumor volume (GTV), with ≥ 66Gy achieving local control of 94.7%. Patients receiving elective nodal irradiation (ENI) had better nodal regional control than those receiving involved field irradiation (IFI). 31 (36%) patients had treatment failure and 15 (17.4%), 8 (9.3%) and 14 (16.2%) patients had local, regional, and distant failure, respectively. 86.7% (13/15) local failures were within GTV, and supraclavicular region (62.5%, 5/8) was the most common regional failure site. No severe toxicities were observed. CONCLUSIONS: Our results seem to indicate that good locoregional control might be achieved for CEC with adequate radiation dose and treatment planning approaches. Impact Journals LLC 2017-02-24 /pmc/articles/PMC5400628/ /pubmed/28423530 http://dx.doi.org/10.18632/oncotarget.15665 Text en Copyright: © 2017 Zhao et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Zhao, Lina Zhou, Yongchun Mu, Yunfeng Chai, Guangjin Xiao, Feng Tan, Lina Lin, Steven H. Shi, Mei Patterns of failure and clinical outcomes of definitive radiotherapy for cervical esophageal cancer |
title | Patterns of failure and clinical outcomes of definitive radiotherapy for cervical esophageal cancer |
title_full | Patterns of failure and clinical outcomes of definitive radiotherapy for cervical esophageal cancer |
title_fullStr | Patterns of failure and clinical outcomes of definitive radiotherapy for cervical esophageal cancer |
title_full_unstemmed | Patterns of failure and clinical outcomes of definitive radiotherapy for cervical esophageal cancer |
title_short | Patterns of failure and clinical outcomes of definitive radiotherapy for cervical esophageal cancer |
title_sort | patterns of failure and clinical outcomes of definitive radiotherapy for cervical esophageal cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400628/ https://www.ncbi.nlm.nih.gov/pubmed/28423530 http://dx.doi.org/10.18632/oncotarget.15665 |
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