JMJD3 suppresses stem cell-like characteristics in breast cancer cells by downregulation of Oct4 independently of its demethylase activity

Epigenetic regulator JMJD3 plays an important role in both tumor progression and somatic cell reprogramming. Here, we explored the effect of JMJD3 on the stem cell-like characteristics of breast cancer and its underlying mechanism involving stemness-related transcription factor Oct4. Our data reveal...

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Detalles Bibliográficos
Autores principales: Xun, Jing, Wang, Dekun, Shen, Long, Gong, Junbo, Gao, Ruifang, Du, Lingfang, Chang, Antao, Song, Xiangrong, Xiang, Rong, Tan, Xiaoyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400634/
https://www.ncbi.nlm.nih.gov/pubmed/28423536
http://dx.doi.org/10.18632/oncotarget.15747

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