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Low vitamin D status is associated with inflammation in patients with prostate cancer

Vitamin D deficiency has been associated with increased risks of prostate cancer. Nevertheless, the mechanisms remain unclear. The aim of this study was to analyze the association among prostate cancer, vitamin D status and inflammation. Sixty patients with newly diagnosed prostate cancer and 120 ag...

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Autores principales: Xie, Dong-Dong, Chen, Yuan-Hua, Xu, Shen, Zhang, Cheng, Wang, Da-Ming, Wang, Hua, Chen, Lei, Zhang, Zhi-Hui, Xia, Mi-Zhen, Xu, De-Xiang, Yu, De-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400647/
https://www.ncbi.nlm.nih.gov/pubmed/28423553
http://dx.doi.org/10.18632/oncotarget.16195
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author Xie, Dong-Dong
Chen, Yuan-Hua
Xu, Shen
Zhang, Cheng
Wang, Da-Ming
Wang, Hua
Chen, Lei
Zhang, Zhi-Hui
Xia, Mi-Zhen
Xu, De-Xiang
Yu, De-Xin
author_facet Xie, Dong-Dong
Chen, Yuan-Hua
Xu, Shen
Zhang, Cheng
Wang, Da-Ming
Wang, Hua
Chen, Lei
Zhang, Zhi-Hui
Xia, Mi-Zhen
Xu, De-Xiang
Yu, De-Xin
author_sort Xie, Dong-Dong
collection PubMed
description Vitamin D deficiency has been associated with increased risks of prostate cancer. Nevertheless, the mechanisms remain unclear. The aim of this study was to analyze the association among prostate cancer, vitamin D status and inflammation. Sixty patients with newly diagnosed prostate cancer and 120 age-matched controls were recruited for this study. Vitamin D status was evaluated and serum inflammatory molecules were measured. Serum 25-(OH)D was lower in patients with prostate cancer. Moreover, serum 25(OH)D was lower in patients with severe prostate cancer than patients with mild and moderate prostate cancer. By contrast, serum C-reactive protein (CRP) and interleukin (IL)-8, two inflammatory molecules, were elevated in patients with prostate cancer. Serum 25-(OH)D was negatively correlated with serum CRP and IL-8 in patients with prostate cancer. Additional analysis showed that the percentage of vitamin D receptor positive nucleus in the prostate was reduced in patients with prostate cancer. By contrast, the percentage of nuclear factor kappa B p65-positive nucleus was elevated in patients with prostate cancer. Our results provide evidence that there is an association among prostate cancer, vitamin D deficiency and inflammatory signaling. Inflammation may be an important mediator for prostate cancer progression in patients with low vitamin D status.
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spelling pubmed-54006472017-05-03 Low vitamin D status is associated with inflammation in patients with prostate cancer Xie, Dong-Dong Chen, Yuan-Hua Xu, Shen Zhang, Cheng Wang, Da-Ming Wang, Hua Chen, Lei Zhang, Zhi-Hui Xia, Mi-Zhen Xu, De-Xiang Yu, De-Xin Oncotarget Research Paper Vitamin D deficiency has been associated with increased risks of prostate cancer. Nevertheless, the mechanisms remain unclear. The aim of this study was to analyze the association among prostate cancer, vitamin D status and inflammation. Sixty patients with newly diagnosed prostate cancer and 120 age-matched controls were recruited for this study. Vitamin D status was evaluated and serum inflammatory molecules were measured. Serum 25-(OH)D was lower in patients with prostate cancer. Moreover, serum 25(OH)D was lower in patients with severe prostate cancer than patients with mild and moderate prostate cancer. By contrast, serum C-reactive protein (CRP) and interleukin (IL)-8, two inflammatory molecules, were elevated in patients with prostate cancer. Serum 25-(OH)D was negatively correlated with serum CRP and IL-8 in patients with prostate cancer. Additional analysis showed that the percentage of vitamin D receptor positive nucleus in the prostate was reduced in patients with prostate cancer. By contrast, the percentage of nuclear factor kappa B p65-positive nucleus was elevated in patients with prostate cancer. Our results provide evidence that there is an association among prostate cancer, vitamin D deficiency and inflammatory signaling. Inflammation may be an important mediator for prostate cancer progression in patients with low vitamin D status. Impact Journals LLC 2017-03-15 /pmc/articles/PMC5400647/ /pubmed/28423553 http://dx.doi.org/10.18632/oncotarget.16195 Text en Copyright: © 2017 Xie et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Xie, Dong-Dong
Chen, Yuan-Hua
Xu, Shen
Zhang, Cheng
Wang, Da-Ming
Wang, Hua
Chen, Lei
Zhang, Zhi-Hui
Xia, Mi-Zhen
Xu, De-Xiang
Yu, De-Xin
Low vitamin D status is associated with inflammation in patients with prostate cancer
title Low vitamin D status is associated with inflammation in patients with prostate cancer
title_full Low vitamin D status is associated with inflammation in patients with prostate cancer
title_fullStr Low vitamin D status is associated with inflammation in patients with prostate cancer
title_full_unstemmed Low vitamin D status is associated with inflammation in patients with prostate cancer
title_short Low vitamin D status is associated with inflammation in patients with prostate cancer
title_sort low vitamin d status is associated with inflammation in patients with prostate cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400647/
https://www.ncbi.nlm.nih.gov/pubmed/28423553
http://dx.doi.org/10.18632/oncotarget.16195
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