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Low vitamin D status is associated with inflammation in patients with prostate cancer
Vitamin D deficiency has been associated with increased risks of prostate cancer. Nevertheless, the mechanisms remain unclear. The aim of this study was to analyze the association among prostate cancer, vitamin D status and inflammation. Sixty patients with newly diagnosed prostate cancer and 120 ag...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400647/ https://www.ncbi.nlm.nih.gov/pubmed/28423553 http://dx.doi.org/10.18632/oncotarget.16195 |
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author | Xie, Dong-Dong Chen, Yuan-Hua Xu, Shen Zhang, Cheng Wang, Da-Ming Wang, Hua Chen, Lei Zhang, Zhi-Hui Xia, Mi-Zhen Xu, De-Xiang Yu, De-Xin |
author_facet | Xie, Dong-Dong Chen, Yuan-Hua Xu, Shen Zhang, Cheng Wang, Da-Ming Wang, Hua Chen, Lei Zhang, Zhi-Hui Xia, Mi-Zhen Xu, De-Xiang Yu, De-Xin |
author_sort | Xie, Dong-Dong |
collection | PubMed |
description | Vitamin D deficiency has been associated with increased risks of prostate cancer. Nevertheless, the mechanisms remain unclear. The aim of this study was to analyze the association among prostate cancer, vitamin D status and inflammation. Sixty patients with newly diagnosed prostate cancer and 120 age-matched controls were recruited for this study. Vitamin D status was evaluated and serum inflammatory molecules were measured. Serum 25-(OH)D was lower in patients with prostate cancer. Moreover, serum 25(OH)D was lower in patients with severe prostate cancer than patients with mild and moderate prostate cancer. By contrast, serum C-reactive protein (CRP) and interleukin (IL)-8, two inflammatory molecules, were elevated in patients with prostate cancer. Serum 25-(OH)D was negatively correlated with serum CRP and IL-8 in patients with prostate cancer. Additional analysis showed that the percentage of vitamin D receptor positive nucleus in the prostate was reduced in patients with prostate cancer. By contrast, the percentage of nuclear factor kappa B p65-positive nucleus was elevated in patients with prostate cancer. Our results provide evidence that there is an association among prostate cancer, vitamin D deficiency and inflammatory signaling. Inflammation may be an important mediator for prostate cancer progression in patients with low vitamin D status. |
format | Online Article Text |
id | pubmed-5400647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-54006472017-05-03 Low vitamin D status is associated with inflammation in patients with prostate cancer Xie, Dong-Dong Chen, Yuan-Hua Xu, Shen Zhang, Cheng Wang, Da-Ming Wang, Hua Chen, Lei Zhang, Zhi-Hui Xia, Mi-Zhen Xu, De-Xiang Yu, De-Xin Oncotarget Research Paper Vitamin D deficiency has been associated with increased risks of prostate cancer. Nevertheless, the mechanisms remain unclear. The aim of this study was to analyze the association among prostate cancer, vitamin D status and inflammation. Sixty patients with newly diagnosed prostate cancer and 120 age-matched controls were recruited for this study. Vitamin D status was evaluated and serum inflammatory molecules were measured. Serum 25-(OH)D was lower in patients with prostate cancer. Moreover, serum 25(OH)D was lower in patients with severe prostate cancer than patients with mild and moderate prostate cancer. By contrast, serum C-reactive protein (CRP) and interleukin (IL)-8, two inflammatory molecules, were elevated in patients with prostate cancer. Serum 25-(OH)D was negatively correlated with serum CRP and IL-8 in patients with prostate cancer. Additional analysis showed that the percentage of vitamin D receptor positive nucleus in the prostate was reduced in patients with prostate cancer. By contrast, the percentage of nuclear factor kappa B p65-positive nucleus was elevated in patients with prostate cancer. Our results provide evidence that there is an association among prostate cancer, vitamin D deficiency and inflammatory signaling. Inflammation may be an important mediator for prostate cancer progression in patients with low vitamin D status. Impact Journals LLC 2017-03-15 /pmc/articles/PMC5400647/ /pubmed/28423553 http://dx.doi.org/10.18632/oncotarget.16195 Text en Copyright: © 2017 Xie et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Xie, Dong-Dong Chen, Yuan-Hua Xu, Shen Zhang, Cheng Wang, Da-Ming Wang, Hua Chen, Lei Zhang, Zhi-Hui Xia, Mi-Zhen Xu, De-Xiang Yu, De-Xin Low vitamin D status is associated with inflammation in patients with prostate cancer |
title | Low vitamin D status is associated with inflammation in patients with prostate cancer |
title_full | Low vitamin D status is associated with inflammation in patients with prostate cancer |
title_fullStr | Low vitamin D status is associated with inflammation in patients with prostate cancer |
title_full_unstemmed | Low vitamin D status is associated with inflammation in patients with prostate cancer |
title_short | Low vitamin D status is associated with inflammation in patients with prostate cancer |
title_sort | low vitamin d status is associated with inflammation in patients with prostate cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400647/ https://www.ncbi.nlm.nih.gov/pubmed/28423553 http://dx.doi.org/10.18632/oncotarget.16195 |
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