Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinoma

The phosphoinositide 3-kinase (PI3K) signaling pathway is the most commonly mutated pathway in head and neck squamous cell carcinoma (HNSCC). There are several drugs targeting members of the PI3K signaling pathway in development for HNSCC. In this article, we review the genetic alterations reported...

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Detalles Bibliográficos
Autores principales: Cai, Yi, Dodhia, Sonam, Su, Gloria H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400658/
https://www.ncbi.nlm.nih.gov/pubmed/28108737
http://dx.doi.org/10.18632/oncotarget.14729
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author Cai, Yi
Dodhia, Sonam
Su, Gloria H
author_facet Cai, Yi
Dodhia, Sonam
Su, Gloria H
author_sort Cai, Yi
collection PubMed
description The phosphoinositide 3-kinase (PI3K) signaling pathway is the most commonly mutated pathway in head and neck squamous cell carcinoma (HNSCC). There are several drugs targeting members of the PI3K signaling pathway in development for HNSCC. In this article, we review the genetic alterations reported in the pathway pertinent to HNSCC, various agents in development targeting various mediators of the pathway, results from clinical trials, and remaining challenges in the development of PI3K pathway inhibitors.
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spelling pubmed-54006582017-05-03 Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinoma Cai, Yi Dodhia, Sonam Su, Gloria H Oncotarget Review The phosphoinositide 3-kinase (PI3K) signaling pathway is the most commonly mutated pathway in head and neck squamous cell carcinoma (HNSCC). There are several drugs targeting members of the PI3K signaling pathway in development for HNSCC. In this article, we review the genetic alterations reported in the pathway pertinent to HNSCC, various agents in development targeting various mediators of the pathway, results from clinical trials, and remaining challenges in the development of PI3K pathway inhibitors. Impact Journals LLC 2017-01-18 /pmc/articles/PMC5400658/ /pubmed/28108737 http://dx.doi.org/10.18632/oncotarget.14729 Text en Copyright: © 2017 Cai et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Review
Cai, Yi
Dodhia, Sonam
Su, Gloria H
Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinoma
title Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinoma
title_full Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinoma
title_fullStr Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinoma
title_full_unstemmed Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinoma
title_short Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinoma
title_sort dysregulations in the pi3k pathway and targeted therapies for head and neck squamous cell carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400658/
https://www.ncbi.nlm.nih.gov/pubmed/28108737
http://dx.doi.org/10.18632/oncotarget.14729
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