Cargando…
Insulin resistance and associated factors: a cross-sectional study of bank employees
OBJECTIVE: Insulin resistance is characterized by the failure of target cells to respond to normal levels of circulating insulin, and this condition is related to cardiovascular disease. This study sought to evaluate the prevalence of insulin resistance and its association with markers of metabolic...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401617/ https://www.ncbi.nlm.nih.gov/pubmed/28492722 http://dx.doi.org/10.6061/clinics/2017(04)06 |
_version_ | 1783231090665717760 |
---|---|
author | Salaroli, Luciane Bresciani Cattafesta, Monica Molina, Maria del Carmen Bisi Zandonade, Eliana Bissoli, Nazaré Souza |
author_facet | Salaroli, Luciane Bresciani Cattafesta, Monica Molina, Maria del Carmen Bisi Zandonade, Eliana Bissoli, Nazaré Souza |
author_sort | Salaroli, Luciane Bresciani |
collection | PubMed |
description | OBJECTIVE: Insulin resistance is characterized by the failure of target cells to respond to normal levels of circulating insulin, and this condition is related to cardiovascular disease. This study sought to evaluate the prevalence of insulin resistance and its association with markers of metabolic abnormalities and metabolic syndrome in bank employees. METHODS: A cross-sectional study was performed on 498 working men and women aged ≥20 years old. The Homeostasis Model Assessment (HOMA-IR) was used to determine the presence of insulin resistance based on cut-off values of ≤2.71 for normal insulin levels and >2.71 for insulin resistance, as established for the adult Brazilian population. RESULTS: It was observed that the 52 (10.4%) overweight individuals with insulin resistance were 4.97 times (95%CI 1.31-18.83) more likely to have high HOMA-IR values than the normal-weight participants; among those who were obese, the likelihood increased to 17.87 (95%CI 4.36-73.21). Individuals with large waist circumferences were 3.27 times (95%CI 1.03-10.38) more likely to develop insulin resistance than those who were within normal parameters. The HOMA-IR values differed between subjects with and without metabolic syndrome, with values of 2.83±2.5 and 1.10±0.81 (p=0.001), respectively. The levels of insulin, ultrasensitive C-reactive protein and uric acid were also associated with insulin resistance. CONCLUSION: The prevalence of insulin resistance among bank employees is high, and insulin resistance is associated with and serves as a marker of metabolic syndrome. Cardiovascular disease and metabolic syndrome-associated metabolic abnormalities were observed, and insulin resistance may be a risk factor in this group of professionals. |
format | Online Article Text |
id | pubmed-5401617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-54016172017-04-23 Insulin resistance and associated factors: a cross-sectional study of bank employees Salaroli, Luciane Bresciani Cattafesta, Monica Molina, Maria del Carmen Bisi Zandonade, Eliana Bissoli, Nazaré Souza Clinics (Sao Paulo) Clinical Science OBJECTIVE: Insulin resistance is characterized by the failure of target cells to respond to normal levels of circulating insulin, and this condition is related to cardiovascular disease. This study sought to evaluate the prevalence of insulin resistance and its association with markers of metabolic abnormalities and metabolic syndrome in bank employees. METHODS: A cross-sectional study was performed on 498 working men and women aged ≥20 years old. The Homeostasis Model Assessment (HOMA-IR) was used to determine the presence of insulin resistance based on cut-off values of ≤2.71 for normal insulin levels and >2.71 for insulin resistance, as established for the adult Brazilian population. RESULTS: It was observed that the 52 (10.4%) overweight individuals with insulin resistance were 4.97 times (95%CI 1.31-18.83) more likely to have high HOMA-IR values than the normal-weight participants; among those who were obese, the likelihood increased to 17.87 (95%CI 4.36-73.21). Individuals with large waist circumferences were 3.27 times (95%CI 1.03-10.38) more likely to develop insulin resistance than those who were within normal parameters. The HOMA-IR values differed between subjects with and without metabolic syndrome, with values of 2.83±2.5 and 1.10±0.81 (p=0.001), respectively. The levels of insulin, ultrasensitive C-reactive protein and uric acid were also associated with insulin resistance. CONCLUSION: The prevalence of insulin resistance among bank employees is high, and insulin resistance is associated with and serves as a marker of metabolic syndrome. Cardiovascular disease and metabolic syndrome-associated metabolic abnormalities were observed, and insulin resistance may be a risk factor in this group of professionals. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2017-04 2017-04 /pmc/articles/PMC5401617/ /pubmed/28492722 http://dx.doi.org/10.6061/clinics/2017(04)06 Text en Copyright © 2017 CLINICS http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited. |
spellingShingle | Clinical Science Salaroli, Luciane Bresciani Cattafesta, Monica Molina, Maria del Carmen Bisi Zandonade, Eliana Bissoli, Nazaré Souza Insulin resistance and associated factors: a cross-sectional study of bank employees |
title | Insulin resistance and associated factors: a cross-sectional study of bank employees |
title_full | Insulin resistance and associated factors: a cross-sectional study of bank employees |
title_fullStr | Insulin resistance and associated factors: a cross-sectional study of bank employees |
title_full_unstemmed | Insulin resistance and associated factors: a cross-sectional study of bank employees |
title_short | Insulin resistance and associated factors: a cross-sectional study of bank employees |
title_sort | insulin resistance and associated factors: a cross-sectional study of bank employees |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401617/ https://www.ncbi.nlm.nih.gov/pubmed/28492722 http://dx.doi.org/10.6061/clinics/2017(04)06 |
work_keys_str_mv | AT salarolilucianebresciani insulinresistanceandassociatedfactorsacrosssectionalstudyofbankemployees AT cattafestamonica insulinresistanceandassociatedfactorsacrosssectionalstudyofbankemployees AT molinamariadelcarmenbisi insulinresistanceandassociatedfactorsacrosssectionalstudyofbankemployees AT zandonadeeliana insulinresistanceandassociatedfactorsacrosssectionalstudyofbankemployees AT bissolinazaresouza insulinresistanceandassociatedfactorsacrosssectionalstudyofbankemployees |