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State-Dependent Modulation of Slow Wave Motifs towards Awakening
Slow cortical waves that propagate across the cerebral cortex forming large-scale spatiotemporal propagation patterns are a hallmark of non-REM sleep and anesthesia, but also occur during resting wakefulness. To investigate how the spatial temporal properties of slow waves change with the depth of a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401891/ https://www.ncbi.nlm.nih.gov/pubmed/28484371 http://dx.doi.org/10.3389/fncel.2017.00108 |
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author | Shimaoka, Daisuke Song, Chenchen Knöpfel, Thomas |
author_facet | Shimaoka, Daisuke Song, Chenchen Knöpfel, Thomas |
author_sort | Shimaoka, Daisuke |
collection | PubMed |
description | Slow cortical waves that propagate across the cerebral cortex forming large-scale spatiotemporal propagation patterns are a hallmark of non-REM sleep and anesthesia, but also occur during resting wakefulness. To investigate how the spatial temporal properties of slow waves change with the depth of anesthetic, we optically imaged population voltage transients generated by mouse layer 2/3 pyramidal neurons across one or two cortical hemispheres dorsally with a genetically encoded voltage indicator (GEVI). From deep barbiturate anesthesia to light barbiturate sedation, depolarizing wave events recruiting at least 50% of the imaged cortical area consistently appeared as a conserved repertoire of distinct wave motifs. Toward awakening, the incidence of individual motifs changed systematically (the motif propagating from visual to motor areas increased while that from somatosensory to visual areas decreased) and both local and global cortical dynamics accelerated. These findings highlight that functional endogenous interactions between distant cortical areas are not only constrained by anatomical connectivity, but can also be modulated by the brain state. |
format | Online Article Text |
id | pubmed-5401891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54018912017-05-08 State-Dependent Modulation of Slow Wave Motifs towards Awakening Shimaoka, Daisuke Song, Chenchen Knöpfel, Thomas Front Cell Neurosci Neuroscience Slow cortical waves that propagate across the cerebral cortex forming large-scale spatiotemporal propagation patterns are a hallmark of non-REM sleep and anesthesia, but also occur during resting wakefulness. To investigate how the spatial temporal properties of slow waves change with the depth of anesthetic, we optically imaged population voltage transients generated by mouse layer 2/3 pyramidal neurons across one or two cortical hemispheres dorsally with a genetically encoded voltage indicator (GEVI). From deep barbiturate anesthesia to light barbiturate sedation, depolarizing wave events recruiting at least 50% of the imaged cortical area consistently appeared as a conserved repertoire of distinct wave motifs. Toward awakening, the incidence of individual motifs changed systematically (the motif propagating from visual to motor areas increased while that from somatosensory to visual areas decreased) and both local and global cortical dynamics accelerated. These findings highlight that functional endogenous interactions between distant cortical areas are not only constrained by anatomical connectivity, but can also be modulated by the brain state. Frontiers Media S.A. 2017-04-24 /pmc/articles/PMC5401891/ /pubmed/28484371 http://dx.doi.org/10.3389/fncel.2017.00108 Text en Copyright © 2017 Shimaoka, Song and Knöpfel. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Shimaoka, Daisuke Song, Chenchen Knöpfel, Thomas State-Dependent Modulation of Slow Wave Motifs towards Awakening |
title | State-Dependent Modulation of Slow Wave Motifs towards Awakening |
title_full | State-Dependent Modulation of Slow Wave Motifs towards Awakening |
title_fullStr | State-Dependent Modulation of Slow Wave Motifs towards Awakening |
title_full_unstemmed | State-Dependent Modulation of Slow Wave Motifs towards Awakening |
title_short | State-Dependent Modulation of Slow Wave Motifs towards Awakening |
title_sort | state-dependent modulation of slow wave motifs towards awakening |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401891/ https://www.ncbi.nlm.nih.gov/pubmed/28484371 http://dx.doi.org/10.3389/fncel.2017.00108 |
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