MicroRNA expression profiling in canine prostate cancer

Canine prostate cancer (cPCa) is an untreatable malignant neoplasm resulting in local tissue invasion and distant metastasis. MicroRNAs (miRs) are small non-coding RNAs that function as oncogenes or tumor suppressors. The purpose of this study was to characterize the expression of miRs that are alte...

Descripción completa

Detalles Bibliográficos
Autores principales: KOBAYASHI, Masanori, SAITO, Akiko, TANAKA, Yoshikazu, MICHISHITA, Masaki, KOBAYASHI, Masato, IRIMAJIRI, Mami, KANEDA, Takeharu, OCHIAI, Kazuhiko, BONKOBARA, Makoto, TAKAHASHI, Kimimasa, HORI, Tatsuya, KAWAKAMI, Eiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2017
Materias:
Theriogenology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402193/
https://www.ncbi.nlm.nih.gov/pubmed/28239051
http://dx.doi.org/10.1292/jvms.16-0279
Descripción
Sumario:Canine prostate cancer (cPCa) is an untreatable malignant neoplasm resulting in local tissue invasion and distant metastasis. MicroRNAs (miRs) are small non-coding RNAs that function as oncogenes or tumor suppressors. The purpose of this study was to characterize the expression of miRs that are altered in cPCa tissue. The expression levels of 277 mature miRs in prostatic tissue (n=5, respectively) were compared between the non-tumor and tumor groups using real-time PCR. Five miRs (miR-18a, 95, 221, 222 and 330) were up-regulated, but 14 miRs (miR-127, 148a, 205, 299, 329b, 335, 376a, 376c, 379, 380, 381, 411, 487b and 495) were down-regulated specifically in cPCa (P<0.05). These miRs have potential use as early diagnosis markers for cPCa and in miR-based therapy.

Ejemplares similares