MicroRNA expression profiling in canine prostate cancer

Canine prostate cancer (cPCa) is an untreatable malignant neoplasm resulting in local tissue invasion and distant metastasis. MicroRNAs (miRs) are small non-coding RNAs that function as oncogenes or tumor suppressors. The purpose of this study was to characterize the expression of miRs that are alte...

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Autores principales: KOBAYASHI, Masanori, SAITO, Akiko, TANAKA, Yoshikazu, MICHISHITA, Masaki, KOBAYASHI, Masato, IRIMAJIRI, Mami, KANEDA, Takeharu, OCHIAI, Kazuhiko, BONKOBARA, Makoto, TAKAHASHI, Kimimasa, HORI, Tatsuya, KAWAKAMI, Eiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2017
Materias:
Theriogenology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402193/
https://www.ncbi.nlm.nih.gov/pubmed/28239051
http://dx.doi.org/10.1292/jvms.16-0279
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author KOBAYASHI, Masanori
SAITO, Akiko
TANAKA, Yoshikazu
MICHISHITA, Masaki
KOBAYASHI, Masato
IRIMAJIRI, Mami
KANEDA, Takeharu
OCHIAI, Kazuhiko
BONKOBARA, Makoto
TAKAHASHI, Kimimasa
HORI, Tatsuya
KAWAKAMI, Eiichi
author_facet KOBAYASHI, Masanori
SAITO, Akiko
TANAKA, Yoshikazu
MICHISHITA, Masaki
KOBAYASHI, Masato
IRIMAJIRI, Mami
KANEDA, Takeharu
OCHIAI, Kazuhiko
BONKOBARA, Makoto
TAKAHASHI, Kimimasa
HORI, Tatsuya
KAWAKAMI, Eiichi
author_sort KOBAYASHI, Masanori
collection PubMed
description Canine prostate cancer (cPCa) is an untreatable malignant neoplasm resulting in local tissue invasion and distant metastasis. MicroRNAs (miRs) are small non-coding RNAs that function as oncogenes or tumor suppressors. The purpose of this study was to characterize the expression of miRs that are altered in cPCa tissue. The expression levels of 277 mature miRs in prostatic tissue (n=5, respectively) were compared between the non-tumor and tumor groups using real-time PCR. Five miRs (miR-18a, 95, 221, 222 and 330) were up-regulated, but 14 miRs (miR-127, 148a, 205, 299, 329b, 335, 376a, 376c, 379, 380, 381, 411, 487b and 495) were down-regulated specifically in cPCa (P<0.05). These miRs have potential use as early diagnosis markers for cPCa and in miR-based therapy.
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spelling pubmed-54021932017-04-27 MicroRNA expression profiling in canine prostate cancer KOBAYASHI, Masanori SAITO, Akiko TANAKA, Yoshikazu MICHISHITA, Masaki KOBAYASHI, Masato IRIMAJIRI, Mami KANEDA, Takeharu OCHIAI, Kazuhiko BONKOBARA, Makoto TAKAHASHI, Kimimasa HORI, Tatsuya KAWAKAMI, Eiichi J Vet Med Sci Theriogenology Canine prostate cancer (cPCa) is an untreatable malignant neoplasm resulting in local tissue invasion and distant metastasis. MicroRNAs (miRs) are small non-coding RNAs that function as oncogenes or tumor suppressors. The purpose of this study was to characterize the expression of miRs that are altered in cPCa tissue. The expression levels of 277 mature miRs in prostatic tissue (n=5, respectively) were compared between the non-tumor and tumor groups using real-time PCR. Five miRs (miR-18a, 95, 221, 222 and 330) were up-regulated, but 14 miRs (miR-127, 148a, 205, 299, 329b, 335, 376a, 376c, 379, 380, 381, 411, 487b and 495) were down-regulated specifically in cPCa (P<0.05). These miRs have potential use as early diagnosis markers for cPCa and in miR-based therapy. The Japanese Society of Veterinary Science 2017-02-27 2017-04 /pmc/articles/PMC5402193/ /pubmed/28239051 http://dx.doi.org/10.1292/jvms.16-0279 Text en ©2017 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: http://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Theriogenology
KOBAYASHI, Masanori
SAITO, Akiko
TANAKA, Yoshikazu
MICHISHITA, Masaki
KOBAYASHI, Masato
IRIMAJIRI, Mami
KANEDA, Takeharu
OCHIAI, Kazuhiko
BONKOBARA, Makoto
TAKAHASHI, Kimimasa
HORI, Tatsuya
KAWAKAMI, Eiichi
MicroRNA expression profiling in canine prostate cancer
title MicroRNA expression profiling in canine prostate cancer
title_full MicroRNA expression profiling in canine prostate cancer
title_fullStr MicroRNA expression profiling in canine prostate cancer
title_full_unstemmed MicroRNA expression profiling in canine prostate cancer
title_short MicroRNA expression profiling in canine prostate cancer
title_sort microrna expression profiling in canine prostate cancer
topic Theriogenology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402193/
https://www.ncbi.nlm.nih.gov/pubmed/28239051
http://dx.doi.org/10.1292/jvms.16-0279
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