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Thermal stability, storage and release of proteins with tailored fit in silica

Biological substances based on proteins, including vaccines, antibodies, and enzymes, typically degrade at room temperature over time due to denaturation, as proteins unfold with loss of secondary and tertiary structure. Their storage and distribution therefore relies on a “cold chain” of continuous...

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Detalles Bibliográficos
Autores principales: Chen, Yun-Chu, Smith, Tristan, Hicks, Robert H., Doekhie, Aswin, Koumanov, Francoise, Wells, Stephen A., Edler, Karen J., van den Elsen, Jean, Holman, Geoffrey D., Marchbank, Kevin J., Sartbaeva, Asel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402271/
https://www.ncbi.nlm.nih.gov/pubmed/28436442
http://dx.doi.org/10.1038/srep46568