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Thermal stability, storage and release of proteins with tailored fit in silica
Biological substances based on proteins, including vaccines, antibodies, and enzymes, typically degrade at room temperature over time due to denaturation, as proteins unfold with loss of secondary and tertiary structure. Their storage and distribution therefore relies on a “cold chain” of continuous...
Autores principales: | Chen, Yun-Chu, Smith, Tristan, Hicks, Robert H., Doekhie, Aswin, Koumanov, Francoise, Wells, Stephen A., Edler, Karen J., van den Elsen, Jean, Holman, Geoffrey D., Marchbank, Kevin J., Sartbaeva, Asel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402271/ https://www.ncbi.nlm.nih.gov/pubmed/28436442 http://dx.doi.org/10.1038/srep46568 |
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