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Functional, thermodynamics, structural and biological studies of in silico-identified inhibitors of Mycobacterium tuberculosis enoyl-ACP(CoA) reductase enzyme

Novel chemotherapeutics agents are needed to kill Mycobacterium tuberculosis, the main causative agent of tuberculosis (TB). The M. tuberculosis 2-trans-enoyl-ACP(CoA) reductase enzyme (MtInhA) is the druggable bona fide target of isoniazid. New chemotypes were previously identified by two in silico...

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Detalles Bibliográficos
Autores principales:	Martinelli, Leonardo K. B., Rotta, Mariane, Villela, Anne D., Rodrigues-Junior, Valnês S., Abbadi, Bruno L., Trindade, Rogério V., Petersen, Guilherme O., Danesi, Giuliano M., Nery, Laura R., Pauli, Ivani, Campos, Maria M., Bonan, Carla D., de Souza, Osmar Norberto, Basso, Luiz A., Santos, Diogenes S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402281/ https://www.ncbi.nlm.nih.gov/pubmed/28436453 http://dx.doi.org/10.1038/srep46696

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