Oxoaporphine Metal Complexes (Co(II), Ni(II), Zn(II)) with High Antitumor Activity by Inducing Mitochondria-Mediated Apoptosis and S-phase Arrest in HepG2

Three new oxoaporphine Co(II), Ni(II) and Zn(II) complexes 1–3 have been synthesized and fully characterized. 1–3 have similar mononuclear structures with the metal and ligand ratio of 1:2. 1–3 exhibited higher cytotoxicity than the OD ligand and cisplatin against HepG2, T-24, BEL-7404, MGC80–3 and...

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Detalles Bibliográficos
Autores principales: Qin, Jiao-Lan, Shen, Wen-Ying, Chen, Zhen-Feng, Zhao, Li-Fang, Qin, Qi-Pin, Yu, Yan-Cheng, Liang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402304/
https://www.ncbi.nlm.nih.gov/pubmed/28436418
http://dx.doi.org/10.1038/srep46056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402304/
https://www.ncbi.nlm.nih.gov/pubmed/28436418
http://dx.doi.org/10.1038/srep46056

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