Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice

Our understanding of development and function of natural killer (NK) cells has progressed significantly in recent years. However, exactly how uterine NK (uNK) cells develop and function is still unclear. To help investigators that are beginning to study tissue NK cells, we summarize in this review o...

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Detalles Bibliográficos
Autores principales: Gaynor, Louise M., Colucci, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402472/
https://www.ncbi.nlm.nih.gov/pubmed/28484462
http://dx.doi.org/10.3389/fimmu.2017.00467
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author Gaynor, Louise M.
Colucci, Francesco
author_facet Gaynor, Louise M.
Colucci, Francesco
author_sort Gaynor, Louise M.
collection PubMed
description Our understanding of development and function of natural killer (NK) cells has progressed significantly in recent years. However, exactly how uterine NK (uNK) cells develop and function is still unclear. To help investigators that are beginning to study tissue NK cells, we summarize in this review our current knowledge of the development and function of uNK cells, and what is yet to be elucidated. We compare and contrast the biology of human and mouse uNK cells in the broader context of the biology of innate lymphoid cells and with reference to peripheral NK cells. We also review how uNK cells may regulate trophoblast invasion and uterine spiral arterial remodeling in human and murine pregnancy.
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spelling pubmed-54024722017-05-08 Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice Gaynor, Louise M. Colucci, Francesco Front Immunol Immunology Our understanding of development and function of natural killer (NK) cells has progressed significantly in recent years. However, exactly how uterine NK (uNK) cells develop and function is still unclear. To help investigators that are beginning to study tissue NK cells, we summarize in this review our current knowledge of the development and function of uNK cells, and what is yet to be elucidated. We compare and contrast the biology of human and mouse uNK cells in the broader context of the biology of innate lymphoid cells and with reference to peripheral NK cells. We also review how uNK cells may regulate trophoblast invasion and uterine spiral arterial remodeling in human and murine pregnancy. Frontiers Media S.A. 2017-04-24 /pmc/articles/PMC5402472/ /pubmed/28484462 http://dx.doi.org/10.3389/fimmu.2017.00467 Text en Copyright © 2017 Gaynor and Colucci. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Gaynor, Louise M.
Colucci, Francesco
Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice
title Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice
title_full Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice
title_fullStr Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice
title_full_unstemmed Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice
title_short Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice
title_sort uterine natural killer cells: functional distinctions and influence on pregnancy in humans and mice
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402472/
https://www.ncbi.nlm.nih.gov/pubmed/28484462
http://dx.doi.org/10.3389/fimmu.2017.00467
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AT coluccifrancesco uterinenaturalkillercellsfunctionaldistinctionsandinfluenceonpregnancyinhumansandmice

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