Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus: A case report

BACKGROUND: This case report describes the use of analysis of cell-free DNA in the blood of a patient with a pregnancy with one live fetus and a choriocarcinoma diagnosed at 22 weeks of gestation. RESULTS: The result of the analysis of 16 microsatellite loci on 14 chromosomes in the cell-free DNA in...

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Detalles Bibliográficos
Autores principales: Kristiansen, Mona Kjaerboel, Niemann, Isa, Lindegaard, Jacob Christian, Christiansen, Mette, Joergensen, Mette Warming, Vogel, Ida, Lildballe, Dorte Launholt, Sunde, Lone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
3500
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402562/
https://www.ncbi.nlm.nih.gov/pubmed/27631219
http://dx.doi.org/10.1097/MD.0000000000004721
Descripción
Sumario:BACKGROUND: This case report describes the use of analysis of cell-free DNA in the blood of a patient with a pregnancy with one live fetus and a choriocarcinoma diagnosed at 22 weeks of gestation. RESULTS: The result of the analysis of 16 microsatellite loci on 14 chromosomes in the cell-free DNA in plasma was consistent with the result of the analysis of a tumor biopsy indicating biparental diploid origin of the genome. The DNA markers were discordant with the markers of the placenta indicating two separate conceptions. CONCLUSION: Our results indicate that analysis of cell-free DNA in plasma allows determination of the origin of a choriocarcinoma without tissue biopsy, even in the presence of a co-existent pregnancy.

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