Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus: A case report

BACKGROUND: This case report describes the use of analysis of cell-free DNA in the blood of a patient with a pregnancy with one live fetus and a choriocarcinoma diagnosed at 22 weeks of gestation. RESULTS: The result of the analysis of 16 microsatellite loci on 14 chromosomes in the cell-free DNA in...

Descripción completa

Detalles Bibliográficos
Autores principales: Kristiansen, Mona Kjaerboel, Niemann, Isa, Lindegaard, Jacob Christian, Christiansen, Mette, Joergensen, Mette Warming, Vogel, Ida, Lildballe, Dorte Launholt, Sunde, Lone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
3500
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402562/
https://www.ncbi.nlm.nih.gov/pubmed/27631219
http://dx.doi.org/10.1097/MD.0000000000004721
_version_ 1783231246019592192
author Kristiansen, Mona Kjaerboel
Niemann, Isa
Lindegaard, Jacob Christian
Christiansen, Mette
Joergensen, Mette Warming
Vogel, Ida
Lildballe, Dorte Launholt
Sunde, Lone
author_facet Kristiansen, Mona Kjaerboel
Niemann, Isa
Lindegaard, Jacob Christian
Christiansen, Mette
Joergensen, Mette Warming
Vogel, Ida
Lildballe, Dorte Launholt
Sunde, Lone
author_sort Kristiansen, Mona Kjaerboel
collection PubMed
description BACKGROUND: This case report describes the use of analysis of cell-free DNA in the blood of a patient with a pregnancy with one live fetus and a choriocarcinoma diagnosed at 22 weeks of gestation. RESULTS: The result of the analysis of 16 microsatellite loci on 14 chromosomes in the cell-free DNA in plasma was consistent with the result of the analysis of a tumor biopsy indicating biparental diploid origin of the genome. The DNA markers were discordant with the markers of the placenta indicating two separate conceptions. CONCLUSION: Our results indicate that analysis of cell-free DNA in plasma allows determination of the origin of a choriocarcinoma without tissue biopsy, even in the presence of a co-existent pregnancy.
format Online
Article
Text
id pubmed-5402562
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-54025622017-04-27 Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus: A case report Kristiansen, Mona Kjaerboel Niemann, Isa Lindegaard, Jacob Christian Christiansen, Mette Joergensen, Mette Warming Vogel, Ida Lildballe, Dorte Launholt Sunde, Lone Medicine (Baltimore) 3500 BACKGROUND: This case report describes the use of analysis of cell-free DNA in the blood of a patient with a pregnancy with one live fetus and a choriocarcinoma diagnosed at 22 weeks of gestation. RESULTS: The result of the analysis of 16 microsatellite loci on 14 chromosomes in the cell-free DNA in plasma was consistent with the result of the analysis of a tumor biopsy indicating biparental diploid origin of the genome. The DNA markers were discordant with the markers of the placenta indicating two separate conceptions. CONCLUSION: Our results indicate that analysis of cell-free DNA in plasma allows determination of the origin of a choriocarcinoma without tissue biopsy, even in the presence of a co-existent pregnancy. Wolters Kluwer Health 2016-09-16 /pmc/articles/PMC5402562/ /pubmed/27631219 http://dx.doi.org/10.1097/MD.0000000000004721 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 3500
Kristiansen, Mona Kjaerboel
Niemann, Isa
Lindegaard, Jacob Christian
Christiansen, Mette
Joergensen, Mette Warming
Vogel, Ida
Lildballe, Dorte Launholt
Sunde, Lone
Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus: A case report
title Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus: A case report
title_full Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus: A case report
title_fullStr Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus: A case report
title_full_unstemmed Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus: A case report
title_short Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus: A case report
title_sort cell-free dna in pregnancy with choriocarcinoma and coexistent live fetus: a case report
topic 3500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402562/
https://www.ncbi.nlm.nih.gov/pubmed/27631219
http://dx.doi.org/10.1097/MD.0000000000004721
work_keys_str_mv AT kristiansenmonakjaerboel cellfreednainpregnancywithchoriocarcinomaandcoexistentlivefetusacasereport
AT niemannisa cellfreednainpregnancywithchoriocarcinomaandcoexistentlivefetusacasereport
AT lindegaardjacobchristian cellfreednainpregnancywithchoriocarcinomaandcoexistentlivefetusacasereport
AT christiansenmette cellfreednainpregnancywithchoriocarcinomaandcoexistentlivefetusacasereport
AT joergensenmettewarming cellfreednainpregnancywithchoriocarcinomaandcoexistentlivefetusacasereport
AT vogelida cellfreednainpregnancywithchoriocarcinomaandcoexistentlivefetusacasereport
AT lildballedortelaunholt cellfreednainpregnancywithchoriocarcinomaandcoexistentlivefetusacasereport
AT sundelone cellfreednainpregnancywithchoriocarcinomaandcoexistentlivefetusacasereport

Ejemplares similares