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Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure
Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and death. Myocardial fibrosis results from increased myofibroblast activity and excessive extracellular matrix deposition. Various cells and molecules are involved in this process, providing targets for poten...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402617/ https://www.ncbi.nlm.nih.gov/pubmed/28484397 http://dx.doi.org/10.3389/fphys.2017.00238 |
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author | Liu, Tong Song, Deli Dong, Jianzeng Zhu, Pinghui Liu, Jie Liu, Wei Ma, Xiaohai Zhao, Lei Ling, Shukuan |
author_facet | Liu, Tong Song, Deli Dong, Jianzeng Zhu, Pinghui Liu, Jie Liu, Wei Ma, Xiaohai Zhao, Lei Ling, Shukuan |
author_sort | Liu, Tong |
collection | PubMed |
description | Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and death. Myocardial fibrosis results from increased myofibroblast activity and excessive extracellular matrix deposition. Various cells and molecules are involved in this process, providing targets for potential drug therapies. Currently, the main detection methods of myocardial fibrosis rely on serum markers, cardiac magnetic resonance imaging, and endomyocardial biopsy. This review summarizes our current knowledge regarding the pathophysiology, quantitative assessment, and novel therapeutic strategies of myocardial fibrosis. |
format | Online Article Text |
id | pubmed-5402617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54026172017-05-08 Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure Liu, Tong Song, Deli Dong, Jianzeng Zhu, Pinghui Liu, Jie Liu, Wei Ma, Xiaohai Zhao, Lei Ling, Shukuan Front Physiol Physiology Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and death. Myocardial fibrosis results from increased myofibroblast activity and excessive extracellular matrix deposition. Various cells and molecules are involved in this process, providing targets for potential drug therapies. Currently, the main detection methods of myocardial fibrosis rely on serum markers, cardiac magnetic resonance imaging, and endomyocardial biopsy. This review summarizes our current knowledge regarding the pathophysiology, quantitative assessment, and novel therapeutic strategies of myocardial fibrosis. Frontiers Media S.A. 2017-04-24 /pmc/articles/PMC5402617/ /pubmed/28484397 http://dx.doi.org/10.3389/fphys.2017.00238 Text en Copyright © 2017 Liu, Song, Dong, Zhu, Liu, Liu, Ma, Zhao and Ling. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Liu, Tong Song, Deli Dong, Jianzeng Zhu, Pinghui Liu, Jie Liu, Wei Ma, Xiaohai Zhao, Lei Ling, Shukuan Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure |
title | Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure |
title_full | Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure |
title_fullStr | Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure |
title_full_unstemmed | Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure |
title_short | Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure |
title_sort | current understanding of the pathophysiology of myocardial fibrosis and its quantitative assessment in heart failure |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402617/ https://www.ncbi.nlm.nih.gov/pubmed/28484397 http://dx.doi.org/10.3389/fphys.2017.00238 |
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