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Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure

Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and death. Myocardial fibrosis results from increased myofibroblast activity and excessive extracellular matrix deposition. Various cells and molecules are involved in this process, providing targets for poten...

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Autores principales: Liu, Tong, Song, Deli, Dong, Jianzeng, Zhu, Pinghui, Liu, Jie, Liu, Wei, Ma, Xiaohai, Zhao, Lei, Ling, Shukuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402617/
https://www.ncbi.nlm.nih.gov/pubmed/28484397
http://dx.doi.org/10.3389/fphys.2017.00238
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author Liu, Tong
Song, Deli
Dong, Jianzeng
Zhu, Pinghui
Liu, Jie
Liu, Wei
Ma, Xiaohai
Zhao, Lei
Ling, Shukuan
author_facet Liu, Tong
Song, Deli
Dong, Jianzeng
Zhu, Pinghui
Liu, Jie
Liu, Wei
Ma, Xiaohai
Zhao, Lei
Ling, Shukuan
author_sort Liu, Tong
collection PubMed
description Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and death. Myocardial fibrosis results from increased myofibroblast activity and excessive extracellular matrix deposition. Various cells and molecules are involved in this process, providing targets for potential drug therapies. Currently, the main detection methods of myocardial fibrosis rely on serum markers, cardiac magnetic resonance imaging, and endomyocardial biopsy. This review summarizes our current knowledge regarding the pathophysiology, quantitative assessment, and novel therapeutic strategies of myocardial fibrosis.
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spelling pubmed-54026172017-05-08 Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure Liu, Tong Song, Deli Dong, Jianzeng Zhu, Pinghui Liu, Jie Liu, Wei Ma, Xiaohai Zhao, Lei Ling, Shukuan Front Physiol Physiology Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and death. Myocardial fibrosis results from increased myofibroblast activity and excessive extracellular matrix deposition. Various cells and molecules are involved in this process, providing targets for potential drug therapies. Currently, the main detection methods of myocardial fibrosis rely on serum markers, cardiac magnetic resonance imaging, and endomyocardial biopsy. This review summarizes our current knowledge regarding the pathophysiology, quantitative assessment, and novel therapeutic strategies of myocardial fibrosis. Frontiers Media S.A. 2017-04-24 /pmc/articles/PMC5402617/ /pubmed/28484397 http://dx.doi.org/10.3389/fphys.2017.00238 Text en Copyright © 2017 Liu, Song, Dong, Zhu, Liu, Liu, Ma, Zhao and Ling. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Liu, Tong
Song, Deli
Dong, Jianzeng
Zhu, Pinghui
Liu, Jie
Liu, Wei
Ma, Xiaohai
Zhao, Lei
Ling, Shukuan
Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure
title Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure
title_full Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure
title_fullStr Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure
title_full_unstemmed Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure
title_short Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure
title_sort current understanding of the pathophysiology of myocardial fibrosis and its quantitative assessment in heart failure
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402617/
https://www.ncbi.nlm.nih.gov/pubmed/28484397
http://dx.doi.org/10.3389/fphys.2017.00238
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