Low body weight and body mass index may be associated with musculoskeletal pain following imatinib discontinuation in chronic myeloid leukemia

It is difficult to predict musculoskeletal pain as a withdrawal syndrome following the discontinuation of imatinib (IM) in patients with chronic myeloid leukemia. We investigated a link between physical size and musculoskeletal pain following IM discontinuation. In total, seven out of 24 patients de...

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Autores principales: Katagiri, Seiichiro, Tauchi, Tetsuzo, Ando, Keiko, Okabe, Seiichi, Gotoh, Moritaka, Ohyashiki, Kazuma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402624/
https://www.ncbi.nlm.nih.gov/pubmed/28462083
http://dx.doi.org/10.1016/j.lrr.2017.04.002
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author Katagiri, Seiichiro
Tauchi, Tetsuzo
Ando, Keiko
Okabe, Seiichi
Gotoh, Moritaka
Ohyashiki, Kazuma
author_facet Katagiri, Seiichiro
Tauchi, Tetsuzo
Ando, Keiko
Okabe, Seiichi
Gotoh, Moritaka
Ohyashiki, Kazuma
author_sort Katagiri, Seiichiro
collection PubMed
description It is difficult to predict musculoskeletal pain as a withdrawal syndrome following the discontinuation of imatinib (IM) in patients with chronic myeloid leukemia. We investigated a link between physical size and musculoskeletal pain following IM discontinuation. In total, seven out of 24 patients developed musculoskeletal pain after discontinuing IM. Those with symptoms had a significantly lower body weight (BW) and body mass index (BMI) than those without symptoms. While previous reports indicated that physical size is associated with the pharmacokinetics of IM, our current study suggests that lower BW and BMI may be associated with musculoskeletal pain following IM discontinuation.
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spelling pubmed-54026242017-05-01 Low body weight and body mass index may be associated with musculoskeletal pain following imatinib discontinuation in chronic myeloid leukemia Katagiri, Seiichiro Tauchi, Tetsuzo Ando, Keiko Okabe, Seiichi Gotoh, Moritaka Ohyashiki, Kazuma Leuk Res Rep Article It is difficult to predict musculoskeletal pain as a withdrawal syndrome following the discontinuation of imatinib (IM) in patients with chronic myeloid leukemia. We investigated a link between physical size and musculoskeletal pain following IM discontinuation. In total, seven out of 24 patients developed musculoskeletal pain after discontinuing IM. Those with symptoms had a significantly lower body weight (BW) and body mass index (BMI) than those without symptoms. While previous reports indicated that physical size is associated with the pharmacokinetics of IM, our current study suggests that lower BW and BMI may be associated with musculoskeletal pain following IM discontinuation. Elsevier 2017-04-12 /pmc/articles/PMC5402624/ /pubmed/28462083 http://dx.doi.org/10.1016/j.lrr.2017.04.002 Text en © 2017 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Katagiri, Seiichiro
Tauchi, Tetsuzo
Ando, Keiko
Okabe, Seiichi
Gotoh, Moritaka
Ohyashiki, Kazuma
Low body weight and body mass index may be associated with musculoskeletal pain following imatinib discontinuation in chronic myeloid leukemia
title Low body weight and body mass index may be associated with musculoskeletal pain following imatinib discontinuation in chronic myeloid leukemia
title_full Low body weight and body mass index may be associated with musculoskeletal pain following imatinib discontinuation in chronic myeloid leukemia
title_fullStr Low body weight and body mass index may be associated with musculoskeletal pain following imatinib discontinuation in chronic myeloid leukemia
title_full_unstemmed Low body weight and body mass index may be associated with musculoskeletal pain following imatinib discontinuation in chronic myeloid leukemia
title_short Low body weight and body mass index may be associated with musculoskeletal pain following imatinib discontinuation in chronic myeloid leukemia
title_sort low body weight and body mass index may be associated with musculoskeletal pain following imatinib discontinuation in chronic myeloid leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402624/
https://www.ncbi.nlm.nih.gov/pubmed/28462083
http://dx.doi.org/10.1016/j.lrr.2017.04.002
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