Cargando…
Effects of Active Site Mutations on Specificity of Nucleobase Binding in Human DNA Polymerase η
[Image: see text] Human DNA polymerase η (Pol η) plays a vital role in protection against skin cancer caused by damage from ultraviolet light. This enzyme rescues stalled replication forks at cyclobutane thymine–thymine dimers (TTDs) by inserting nucleotides opposite these DNA lesions. Residue R61 i...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2016
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402696/ https://www.ncbi.nlm.nih.gov/pubmed/28423907 http://dx.doi.org/10.1021/acs.jpcb.6b09973 |