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Effects of Active Site Mutations on Specificity of Nucleobase Binding in Human DNA Polymerase η

[Image: see text] Human DNA polymerase η (Pol η) plays a vital role in protection against skin cancer caused by damage from ultraviolet light. This enzyme rescues stalled replication forks at cyclobutane thymine–thymine dimers (TTDs) by inserting nucleotides opposite these DNA lesions. Residue R61 i...

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Detalles Bibliográficos
Autores principales:	Ucisik, Melek N., Hammes-Schiffer, Sharon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402696/ https://www.ncbi.nlm.nih.gov/pubmed/28423907 http://dx.doi.org/10.1021/acs.jpcb.6b09973

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