A novel inhibitor of active protein kinase G attenuates chronic inflammatory and osteoarthritic pain

Activating PKG-1α induces a long-term hyperexcitability (LTH) in nociceptive neurons. Since the LTH correlates directly with chronic pain in many animal models, we tested the hypothesis that inhibiting PKG-1α would attenuate LTH-mediated pain. We first synthesized and characterized compound N46 (N-(...

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Detalles Bibliográficos
Autores principales: Sung, Ying-Ju, Sofoluke, Nelson, Nkamany, Mary, Deng, Shixian, Xie, Yuli, Greenwood, Jeremy, Farid, Ramy, Landry, Donald W., Ambron, Richard T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402717/
https://www.ncbi.nlm.nih.gov/pubmed/28059868
http://dx.doi.org/10.1097/j.pain.0000000000000832

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