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Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci

The epidemiologically most important mechanism of antibiotic resistance in Staphylococcus aureus is associated with mecA–an acquired gene encoding an extra penicillin-binding protein (PBP2a) with low affinity to virtually all β-lactams. The introduction of mecA into the S. aureus chromosome has led...

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Detalles Bibliográficos
Autores principales:	Rolo, Joana, Worning, Peder, Boye Nielsen, Jesper, Sobral, Rita, Bowden, Rory, Bouchami, Ons, Damborg, Peter, Guardabassi, Luca, Perreten, Vincent, Westh, Henrik, Tomasz, Alexander, de Lencastre, Hermínia, Miragaia, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402963/ https://www.ncbi.nlm.nih.gov/pubmed/28394942 http://dx.doi.org/10.1371/journal.pgen.1006674

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