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Mutant uromodulin expression leads to altered homeostasis of the endoplasmic reticulum and activates the unfolded protein response

Uromodulin is the most abundant urinary protein in physiological conditions. It is exclusively produced by renal epithelial cells lining the thick ascending limb of Henle’s loop (TAL) and it plays key roles in kidney function and disease. Mutations in UMOD, the gene encoding uromodulin, cause autoso...

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Detalles Bibliográficos
Autores principales:	Schaeffer, Céline, Merella, Stefania, Pasqualetto, Elena, Lazarevic, Dejan, Rampoldi, Luca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402980/ https://www.ncbi.nlm.nih.gov/pubmed/28437467 http://dx.doi.org/10.1371/journal.pone.0175970

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