YEATS domain: Linking histone crotonylation to gene regulation

Recent research reveals that the YEATS domains preferentially recognize crotonylated lysines on histones. Here, we discuss the molecular mechanisms that enable this recognition and the biological significances of this interaction. The dynamics of histone crotonylation and its potential roles in the...

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Detalles Bibliográficos
Autores principales: Li, Yuanyuan, Zhao, Dan, Chen, Zhonglei, Li, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Point-of-View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402991/
https://www.ncbi.nlm.nih.gov/pubmed/27661789
http://dx.doi.org/10.1080/21541264.2016.1239602
Descripción
Sumario:Recent research reveals that the YEATS domains preferentially recognize crotonylated lysines on histones. Here, we discuss the molecular mechanisms that enable this recognition and the biological significances of this interaction. The dynamics of histone crotonylation and its potential roles in the regulation of gene expression will also be discussed.

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