Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium

Escalating resistance to azithromycin and moxifloxacin is being reported for Mycoplasma genitalium in the Asia-Pacific region. Analyzing 140 infections, we found pretreatment fluoroquinolone-resistance mutations in parC (13.6%) and gyrA (5%). ParC S83 changes were associated with moxifloxacin failur...

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Autores principales: Murray, Gerald L., Bradshaw, Catriona S., Bissessor, Melanie, Danielewski, Jennifer, Garland, Suzanne M., Jensen, Jørgen S., Fairley, Christopher K., Tabrizi, Sepehr N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403035/
https://www.ncbi.nlm.nih.gov/pubmed/28418319
http://dx.doi.org/10.3201/eid2305.161745
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author Murray, Gerald L.
Bradshaw, Catriona S.
Bissessor, Melanie
Danielewski, Jennifer
Garland, Suzanne M.
Jensen, Jørgen S.
Fairley, Christopher K.
Tabrizi, Sepehr N.
author_facet Murray, Gerald L.
Bradshaw, Catriona S.
Bissessor, Melanie
Danielewski, Jennifer
Garland, Suzanne M.
Jensen, Jørgen S.
Fairley, Christopher K.
Tabrizi, Sepehr N.
author_sort Murray, Gerald L.
collection PubMed
description Escalating resistance to azithromycin and moxifloxacin is being reported for Mycoplasma genitalium in the Asia-Pacific region. Analyzing 140 infections, we found pretreatment fluoroquinolone-resistance mutations in parC (13.6%) and gyrA (5%). ParC S83 changes were associated with moxifloxacin failure. Combined macrolide/fluoroquinolone-resistance mutations were in 8.6% of specimens, for which recommended therapies would be ineffective.
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spelling pubmed-54030352017-05-12 Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium Murray, Gerald L. Bradshaw, Catriona S. Bissessor, Melanie Danielewski, Jennifer Garland, Suzanne M. Jensen, Jørgen S. Fairley, Christopher K. Tabrizi, Sepehr N. Emerg Infect Dis Dispatch Escalating resistance to azithromycin and moxifloxacin is being reported for Mycoplasma genitalium in the Asia-Pacific region. Analyzing 140 infections, we found pretreatment fluoroquinolone-resistance mutations in parC (13.6%) and gyrA (5%). ParC S83 changes were associated with moxifloxacin failure. Combined macrolide/fluoroquinolone-resistance mutations were in 8.6% of specimens, for which recommended therapies would be ineffective. Centers for Disease Control and Prevention 2017-05 /pmc/articles/PMC5403035/ /pubmed/28418319 http://dx.doi.org/10.3201/eid2305.161745 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Murray, Gerald L.
Bradshaw, Catriona S.
Bissessor, Melanie
Danielewski, Jennifer
Garland, Suzanne M.
Jensen, Jørgen S.
Fairley, Christopher K.
Tabrizi, Sepehr N.
Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium
title Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium
title_full Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium
title_fullStr Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium
title_full_unstemmed Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium
title_short Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium
title_sort increasing macrolide and fluoroquinolone resistance in mycoplasma genitalium
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403035/
https://www.ncbi.nlm.nih.gov/pubmed/28418319
http://dx.doi.org/10.3201/eid2305.161745
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