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Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection

Cross-reactive antibodies elicited by dengue virus (DENV) infection might affect Zika virus infection and confound serologic tests. Recent data demonstrate neutralization of Zika virus by monoclonal antibodies or human serum collected early after DENV infection. Whether this finding is true in late...

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Autores principales: Collins, Matthew H., McGowan, Eileen, Jadi, Ramesh, Young, Ellen, Lopez, Cesar A., Baric, Ralph S., Lazear, Helen M., de Silva, Aravinda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403059/
https://www.ncbi.nlm.nih.gov/pubmed/28418292
http://dx.doi.org/10.3201/eid2305.161630
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author Collins, Matthew H.
McGowan, Eileen
Jadi, Ramesh
Young, Ellen
Lopez, Cesar A.
Baric, Ralph S.
Lazear, Helen M.
de Silva, Aravinda M.
author_facet Collins, Matthew H.
McGowan, Eileen
Jadi, Ramesh
Young, Ellen
Lopez, Cesar A.
Baric, Ralph S.
Lazear, Helen M.
de Silva, Aravinda M.
author_sort Collins, Matthew H.
collection PubMed
description Cross-reactive antibodies elicited by dengue virus (DENV) infection might affect Zika virus infection and confound serologic tests. Recent data demonstrate neutralization of Zika virus by monoclonal antibodies or human serum collected early after DENV infection. Whether this finding is true in late DENV convalescence (>6 months after infection) is unknown. We studied late convalescent serum samples from persons with prior DENV or Zika virus exposure. Despite extensive cross-reactivity in IgG binding, Zika virus neutralization was not observed among primary DENV infections. We observed low-frequency (23%) Zika virus cross-neutralization in repeat DENV infections. DENV-immune persons who had Zika virus as a secondary infection had distinct populations of antibodies that neutralized DENVs and Zika virus, as shown by DENV-reactive antibody depletion experiments. These data suggest that most DENV infections do not induce durable, high-level Zika virus cross-neutralizing antibodies. Zika virus–specific antibody populations develop after Zika virus infection irrespective of prior DENV immunity.
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spelling pubmed-54030592017-05-12 Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection Collins, Matthew H. McGowan, Eileen Jadi, Ramesh Young, Ellen Lopez, Cesar A. Baric, Ralph S. Lazear, Helen M. de Silva, Aravinda M. Emerg Infect Dis Research Cross-reactive antibodies elicited by dengue virus (DENV) infection might affect Zika virus infection and confound serologic tests. Recent data demonstrate neutralization of Zika virus by monoclonal antibodies or human serum collected early after DENV infection. Whether this finding is true in late DENV convalescence (>6 months after infection) is unknown. We studied late convalescent serum samples from persons with prior DENV or Zika virus exposure. Despite extensive cross-reactivity in IgG binding, Zika virus neutralization was not observed among primary DENV infections. We observed low-frequency (23%) Zika virus cross-neutralization in repeat DENV infections. DENV-immune persons who had Zika virus as a secondary infection had distinct populations of antibodies that neutralized DENVs and Zika virus, as shown by DENV-reactive antibody depletion experiments. These data suggest that most DENV infections do not induce durable, high-level Zika virus cross-neutralizing antibodies. Zika virus–specific antibody populations develop after Zika virus infection irrespective of prior DENV immunity. Centers for Disease Control and Prevention 2017-05 /pmc/articles/PMC5403059/ /pubmed/28418292 http://dx.doi.org/10.3201/eid2305.161630 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Collins, Matthew H.
McGowan, Eileen
Jadi, Ramesh
Young, Ellen
Lopez, Cesar A.
Baric, Ralph S.
Lazear, Helen M.
de Silva, Aravinda M.
Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection
title Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection
title_full Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection
title_fullStr Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection
title_full_unstemmed Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection
title_short Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection
title_sort lack of durable cross-neutralizing antibodies against zika virus from dengue virus infection
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403059/
https://www.ncbi.nlm.nih.gov/pubmed/28418292
http://dx.doi.org/10.3201/eid2305.161630
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