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Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma: Case report

RATIONALE: Diffuse melanosis cutis (DMC) is a very rare sign of malignant melanoma progression. The condition usually develops after approximately one year from melanoma diagnosis in a patient with metastatic tumors and after anticancer treatment with cytostatic medications. PATIENT CONCERNS: A 72-y...

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Autores principales: Maj, Joanna, Jankowska-Konsur, Alina, Gruber, Joanna, Woźniak, Zdzisław, Nockowski, Piotr, Hryncewicz-Gwóźdź, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403073/
https://www.ncbi.nlm.nih.gov/pubmed/28403076
http://dx.doi.org/10.1097/MD.0000000000006470
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author Maj, Joanna
Jankowska-Konsur, Alina
Gruber, Joanna
Woźniak, Zdzisław
Nockowski, Piotr
Hryncewicz-Gwóźdź, Anita
author_facet Maj, Joanna
Jankowska-Konsur, Alina
Gruber, Joanna
Woźniak, Zdzisław
Nockowski, Piotr
Hryncewicz-Gwóźdź, Anita
author_sort Maj, Joanna
collection PubMed
description RATIONALE: Diffuse melanosis cutis (DMC) is a very rare sign of malignant melanoma progression. The condition usually develops after approximately one year from melanoma diagnosis in a patient with metastatic tumors and after anticancer treatment with cytostatic medications. PATIENT CONCERNS: A 72-year old Caucasian man was admitted to the Department of Dermatology with DMC for 4 months and the history of two melanomas treated surgically 30 years and 9 months before present hospitalization. DIAGNOSIS: Histological and immunohistochemical examinations of DMC biopsy indicated melanoma metastatic cells as well as free deposits of melanin and melanophage presence in the dermis. INTERVENTIONS: The patient refused to the treatment. OUTCOMES: The patient died eight months after DMC appeared. LESSONS: DMC is a rare presentation of advanced MM and is a bad prognostic factor. The pathomechanisms of the discoloration of the skin are not fully explained. The role of micrometastases, as well as melanin precursors, released during lysis of MM metastases, and growth factors may play a role in the development of the symptom.
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spelling pubmed-54030732017-04-28 Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma: Case report Maj, Joanna Jankowska-Konsur, Alina Gruber, Joanna Woźniak, Zdzisław Nockowski, Piotr Hryncewicz-Gwóźdź, Anita Medicine (Baltimore) 4000 RATIONALE: Diffuse melanosis cutis (DMC) is a very rare sign of malignant melanoma progression. The condition usually develops after approximately one year from melanoma diagnosis in a patient with metastatic tumors and after anticancer treatment with cytostatic medications. PATIENT CONCERNS: A 72-year old Caucasian man was admitted to the Department of Dermatology with DMC for 4 months and the history of two melanomas treated surgically 30 years and 9 months before present hospitalization. DIAGNOSIS: Histological and immunohistochemical examinations of DMC biopsy indicated melanoma metastatic cells as well as free deposits of melanin and melanophage presence in the dermis. INTERVENTIONS: The patient refused to the treatment. OUTCOMES: The patient died eight months after DMC appeared. LESSONS: DMC is a rare presentation of advanced MM and is a bad prognostic factor. The pathomechanisms of the discoloration of the skin are not fully explained. The role of micrometastases, as well as melanin precursors, released during lysis of MM metastases, and growth factors may play a role in the development of the symptom. Wolters Kluwer Health 2017-04-14 /pmc/articles/PMC5403073/ /pubmed/28403076 http://dx.doi.org/10.1097/MD.0000000000006470 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-sa/4.0 This is an open access article distributed under the Creative Commons Attribution-Share Alike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-sa/4.0
spellingShingle 4000
Maj, Joanna
Jankowska-Konsur, Alina
Gruber, Joanna
Woźniak, Zdzisław
Nockowski, Piotr
Hryncewicz-Gwóźdź, Anita
Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma: Case report
title Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma: Case report
title_full Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma: Case report
title_fullStr Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma: Case report
title_full_unstemmed Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma: Case report
title_short Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma: Case report
title_sort diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma: case report
topic 4000
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403073/
https://www.ncbi.nlm.nih.gov/pubmed/28403076
http://dx.doi.org/10.1097/MD.0000000000006470
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