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Low serum levels of uric acid and albumin in patients with Guillain–Barre syndrome
Free radical toxicity due to poorly maintained cellular redox levels is crucial events that have been associated with the pathogenesis of Guillain–Barre syndrome (GBS) patients. Uric acid (UA) and albumin correlate with oxidative stress in some degree. We aimed to evaluate the relationship between G...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403106/ https://www.ncbi.nlm.nih.gov/pubmed/28403109 http://dx.doi.org/10.1097/MD.0000000000006618 |
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author | Su, Zhongqian Chen, Zhibo Xiang, Yian Wang, Bingjie Huang, Yuanyuan Yang, Dehao Li, Xiang Weng, Yiyun Lin, XianFeng Chen, Guoqian Liu, Wenyue Zhao, Chenchen Wang, Qingqing Li, Shanshan Chen, Ying Chen, Ying Quan, Weiwei Tong, Qiuling Wu, Shengjie Huang, Shihao Mei, Peina Li, Zhengzheng Li, Jia Hou, Shengtao Zhang, Xu |
author_facet | Su, Zhongqian Chen, Zhibo Xiang, Yian Wang, Bingjie Huang, Yuanyuan Yang, Dehao Li, Xiang Weng, Yiyun Lin, XianFeng Chen, Guoqian Liu, Wenyue Zhao, Chenchen Wang, Qingqing Li, Shanshan Chen, Ying Chen, Ying Quan, Weiwei Tong, Qiuling Wu, Shengjie Huang, Shihao Mei, Peina Li, Zhengzheng Li, Jia Hou, Shengtao Zhang, Xu |
author_sort | Su, Zhongqian |
collection | PubMed |
description | Free radical toxicity due to poorly maintained cellular redox levels is crucial events that have been associated with the pathogenesis of Guillain–Barre syndrome (GBS) patients. Uric acid (UA) and albumin correlate with oxidative stress in some degree. We aimed to evaluate the relationship between GBS and serum levels of UA and albumin in the present study. The serum levels of UA and albumin were determined in 203 individuals including 88 patients with GBS and 153 healthy controls (HC). We found that serum levels of UA and albumin in patients with GBS were significantly lower than those in HC group. Besides, similar phenomenon was observed when the male and female subgroups were estimated, respectively. Additionally, we found that there is no statistic difference among subgroups of GBS regarding UA and albumin. The univariate analysis revealed that both the high UA and high albumin were protective factors for patients with GBS (odds ratio [OR] 0.140; 95% confidence interval [CI]: 0.074–0.264; P < .001 and OR 0.016; 95% CI: 0.006–0.038; P < .001, respectively). It was further confirmed by the multivariable logistic regression analysis after adjusting for other potential confounding factors (OR 0.168; 95% CI: 0.055–0.514; P = .002 and OR 0.027; 95% CI: 0.011–0.071; P < .001, respectively). In conclusion, we found that patients with GBS had significantly low serum UA and albumin levels. Moreover, we demonstrated that both the high UA and high albumin were protective factors for patients with GBS. |
format | Online Article Text |
id | pubmed-5403106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-54031062017-04-28 Low serum levels of uric acid and albumin in patients with Guillain–Barre syndrome Su, Zhongqian Chen, Zhibo Xiang, Yian Wang, Bingjie Huang, Yuanyuan Yang, Dehao Li, Xiang Weng, Yiyun Lin, XianFeng Chen, Guoqian Liu, Wenyue Zhao, Chenchen Wang, Qingqing Li, Shanshan Chen, Ying Chen, Ying Quan, Weiwei Tong, Qiuling Wu, Shengjie Huang, Shihao Mei, Peina Li, Zhengzheng Li, Jia Hou, Shengtao Zhang, Xu Medicine (Baltimore) 5300 Free radical toxicity due to poorly maintained cellular redox levels is crucial events that have been associated with the pathogenesis of Guillain–Barre syndrome (GBS) patients. Uric acid (UA) and albumin correlate with oxidative stress in some degree. We aimed to evaluate the relationship between GBS and serum levels of UA and albumin in the present study. The serum levels of UA and albumin were determined in 203 individuals including 88 patients with GBS and 153 healthy controls (HC). We found that serum levels of UA and albumin in patients with GBS were significantly lower than those in HC group. Besides, similar phenomenon was observed when the male and female subgroups were estimated, respectively. Additionally, we found that there is no statistic difference among subgroups of GBS regarding UA and albumin. The univariate analysis revealed that both the high UA and high albumin were protective factors for patients with GBS (odds ratio [OR] 0.140; 95% confidence interval [CI]: 0.074–0.264; P < .001 and OR 0.016; 95% CI: 0.006–0.038; P < .001, respectively). It was further confirmed by the multivariable logistic regression analysis after adjusting for other potential confounding factors (OR 0.168; 95% CI: 0.055–0.514; P = .002 and OR 0.027; 95% CI: 0.011–0.071; P < .001, respectively). In conclusion, we found that patients with GBS had significantly low serum UA and albumin levels. Moreover, we demonstrated that both the high UA and high albumin were protective factors for patients with GBS. Wolters Kluwer Health 2017-04-14 /pmc/articles/PMC5403106/ /pubmed/28403109 http://dx.doi.org/10.1097/MD.0000000000006618 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0 |
spellingShingle | 5300 Su, Zhongqian Chen, Zhibo Xiang, Yian Wang, Bingjie Huang, Yuanyuan Yang, Dehao Li, Xiang Weng, Yiyun Lin, XianFeng Chen, Guoqian Liu, Wenyue Zhao, Chenchen Wang, Qingqing Li, Shanshan Chen, Ying Chen, Ying Quan, Weiwei Tong, Qiuling Wu, Shengjie Huang, Shihao Mei, Peina Li, Zhengzheng Li, Jia Hou, Shengtao Zhang, Xu Low serum levels of uric acid and albumin in patients with Guillain–Barre syndrome |
title | Low serum levels of uric acid and albumin in patients with Guillain–Barre syndrome |
title_full | Low serum levels of uric acid and albumin in patients with Guillain–Barre syndrome |
title_fullStr | Low serum levels of uric acid and albumin in patients with Guillain–Barre syndrome |
title_full_unstemmed | Low serum levels of uric acid and albumin in patients with Guillain–Barre syndrome |
title_short | Low serum levels of uric acid and albumin in patients with Guillain–Barre syndrome |
title_sort | low serum levels of uric acid and albumin in patients with guillain–barre syndrome |
topic | 5300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403106/ https://www.ncbi.nlm.nih.gov/pubmed/28403109 http://dx.doi.org/10.1097/MD.0000000000006618 |
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