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A novel t(9;22;11) translocation involving 11q24 in a patient with chronic myeloid leukemia: A case report
Variant Philadelphia chromosome translocations involving chromosomes other than 9 and 22 have been reported in 5–10% of patients with chronic myeloid leukemia (CML). As part of the three-way variant t(9;22;11) in patients with CML, 11q24 is a novel region that has not previously been investigated. A...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403192/ https://www.ncbi.nlm.nih.gov/pubmed/28454313 http://dx.doi.org/10.3892/ol.2017.5668 |
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author | Lee, Jaehyeon Kim, Dal Sik Lee, Hye Soo Choi, Sam Im Cho, Yong Gon |
author_facet | Lee, Jaehyeon Kim, Dal Sik Lee, Hye Soo Choi, Sam Im Cho, Yong Gon |
author_sort | Lee, Jaehyeon |
collection | PubMed |
description | Variant Philadelphia chromosome translocations involving chromosomes other than 9 and 22 have been reported in 5–10% of patients with chronic myeloid leukemia (CML). As part of the three-way variant t(9;22;11) in patients with CML, 11q24 is a novel region that has not previously been investigated. A 22-year-old male exhibiting chronic phase CML developed a recurrence of the same phase subsequent to the interruption of imatinib treatment and showed the same chromosomal abnormality, t(9;22;11)(q34;q11.2;q24), that was detected at the initial diagnosis. The recurrent CML responded well to imatinib therapy. These findings suggest that the three-way variant, t(9;22;11), involving 11q24 may be associated with a good prognosis and response to imatinib. This is the first report of three-way variant involving 11q24 in a patient with CML. |
format | Online Article Text |
id | pubmed-5403192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-54031922017-04-27 A novel t(9;22;11) translocation involving 11q24 in a patient with chronic myeloid leukemia: A case report Lee, Jaehyeon Kim, Dal Sik Lee, Hye Soo Choi, Sam Im Cho, Yong Gon Oncol Lett Articles Variant Philadelphia chromosome translocations involving chromosomes other than 9 and 22 have been reported in 5–10% of patients with chronic myeloid leukemia (CML). As part of the three-way variant t(9;22;11) in patients with CML, 11q24 is a novel region that has not previously been investigated. A 22-year-old male exhibiting chronic phase CML developed a recurrence of the same phase subsequent to the interruption of imatinib treatment and showed the same chromosomal abnormality, t(9;22;11)(q34;q11.2;q24), that was detected at the initial diagnosis. The recurrent CML responded well to imatinib therapy. These findings suggest that the three-way variant, t(9;22;11), involving 11q24 may be associated with a good prognosis and response to imatinib. This is the first report of three-way variant involving 11q24 in a patient with CML. D.A. Spandidos 2017-03 2017-02-01 /pmc/articles/PMC5403192/ /pubmed/28454313 http://dx.doi.org/10.3892/ol.2017.5668 Text en Copyright: © Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Lee, Jaehyeon Kim, Dal Sik Lee, Hye Soo Choi, Sam Im Cho, Yong Gon A novel t(9;22;11) translocation involving 11q24 in a patient with chronic myeloid leukemia: A case report |
title | A novel t(9;22;11) translocation involving 11q24 in a patient with chronic myeloid leukemia: A case report |
title_full | A novel t(9;22;11) translocation involving 11q24 in a patient with chronic myeloid leukemia: A case report |
title_fullStr | A novel t(9;22;11) translocation involving 11q24 in a patient with chronic myeloid leukemia: A case report |
title_full_unstemmed | A novel t(9;22;11) translocation involving 11q24 in a patient with chronic myeloid leukemia: A case report |
title_short | A novel t(9;22;11) translocation involving 11q24 in a patient with chronic myeloid leukemia: A case report |
title_sort | novel t(9;22;11) translocation involving 11q24 in a patient with chronic myeloid leukemia: a case report |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403192/ https://www.ncbi.nlm.nih.gov/pubmed/28454313 http://dx.doi.org/10.3892/ol.2017.5668 |
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