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Philadelphia chromosome with acute myeloid leukemia and concurrent large B cell lymphoma of different origins: A case report
Philadelphia chromosome with de novo acute myeloid leukemia (Ph + AML) arising from t(9;22) is an uncommon occurrence. Ph + AML is known to respond poorly to conventional chemotherapy. To the best of our knowledge, simultaneous diagnosis of de novo Ph + AML and lymphoma in a single patient has not y...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403225/ https://www.ncbi.nlm.nih.gov/pubmed/28454232 http://dx.doi.org/10.3892/ol.2017.5578 |
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author | Dai, Yang Shuai, Xiao Kuang, Pu Wang, Lin Liu, Ting Niu, Ting |
author_facet | Dai, Yang Shuai, Xiao Kuang, Pu Wang, Lin Liu, Ting Niu, Ting |
author_sort | Dai, Yang |
collection | PubMed |
description | Philadelphia chromosome with de novo acute myeloid leukemia (Ph + AML) arising from t(9;22) is an uncommon occurrence. Ph + AML is known to respond poorly to conventional chemotherapy. To the best of our knowledge, simultaneous diagnosis of de novo Ph + AML and lymphoma in a single patient has not yet been reported. The present study reports the case of a 37-year-old female patient who presented with bone pain, fever and lymphadenopathy, and was diagnosed as Ph + AML with concurrent diffuse large B cell lymphoma. Combined chemotherapy regimen covering AML and lymphoma was administered, achieving short-term response. However, the therapy soon failed and the patient succumbed to the disease. The present study reports the first case of Ph + AML occurring concurrently with diffuse large B cell lymphoma, and discusses certain differences between Ph + AML and chronic myelogenous leukemia in the myeloid blast crisis phase, as well as the appropriate therapeutic modalities for Ph + AML. In addition, the potential association between Ph + AML and diffuse large B cell lymphoma in this patient was investigated. |
format | Online Article Text |
id | pubmed-5403225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-54032252017-04-27 Philadelphia chromosome with acute myeloid leukemia and concurrent large B cell lymphoma of different origins: A case report Dai, Yang Shuai, Xiao Kuang, Pu Wang, Lin Liu, Ting Niu, Ting Oncol Lett Articles Philadelphia chromosome with de novo acute myeloid leukemia (Ph + AML) arising from t(9;22) is an uncommon occurrence. Ph + AML is known to respond poorly to conventional chemotherapy. To the best of our knowledge, simultaneous diagnosis of de novo Ph + AML and lymphoma in a single patient has not yet been reported. The present study reports the case of a 37-year-old female patient who presented with bone pain, fever and lymphadenopathy, and was diagnosed as Ph + AML with concurrent diffuse large B cell lymphoma. Combined chemotherapy regimen covering AML and lymphoma was administered, achieving short-term response. However, the therapy soon failed and the patient succumbed to the disease. The present study reports the first case of Ph + AML occurring concurrently with diffuse large B cell lymphoma, and discusses certain differences between Ph + AML and chronic myelogenous leukemia in the myeloid blast crisis phase, as well as the appropriate therapeutic modalities for Ph + AML. In addition, the potential association between Ph + AML and diffuse large B cell lymphoma in this patient was investigated. D.A. Spandidos 2017-03 2017-01-10 /pmc/articles/PMC5403225/ /pubmed/28454232 http://dx.doi.org/10.3892/ol.2017.5578 Text en Copyright: © Dai et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Dai, Yang Shuai, Xiao Kuang, Pu Wang, Lin Liu, Ting Niu, Ting Philadelphia chromosome with acute myeloid leukemia and concurrent large B cell lymphoma of different origins: A case report |
title | Philadelphia chromosome with acute myeloid leukemia and concurrent large B cell lymphoma of different origins: A case report |
title_full | Philadelphia chromosome with acute myeloid leukemia and concurrent large B cell lymphoma of different origins: A case report |
title_fullStr | Philadelphia chromosome with acute myeloid leukemia and concurrent large B cell lymphoma of different origins: A case report |
title_full_unstemmed | Philadelphia chromosome with acute myeloid leukemia and concurrent large B cell lymphoma of different origins: A case report |
title_short | Philadelphia chromosome with acute myeloid leukemia and concurrent large B cell lymphoma of different origins: A case report |
title_sort | philadelphia chromosome with acute myeloid leukemia and concurrent large b cell lymphoma of different origins: a case report |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403225/ https://www.ncbi.nlm.nih.gov/pubmed/28454232 http://dx.doi.org/10.3892/ol.2017.5578 |
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