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2-Methoxyestradiol enhances radiosensitivity in radioresistant melanoma MDA-MB-435R cells by regulating glycolysis via HIF-1α/PDK1 axis

HIF-1α overexpression is associated with radio-resistance of various cancers. A radioresistant human melanoma cell model MDA-MB-435R (435R) was established by us previously. Compared with the parental cells MDA-MB-435 (435S), an elevated level of HIF-1α expression in 435R cells was demonstrated in o...

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Detalles Bibliográficos
Autores principales:	Zhao, Hong, Jiang, Huangang, Li, Zheng, Zhuang, Yafei, Liu, Yinyin, Zhou, Shuliang, Xiao, Youde, Xie, Conghua, Zhou, Fuxiang, Zhou, Yunfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403226/ https://www.ncbi.nlm.nih.gov/pubmed/28339028 http://dx.doi.org/10.3892/ijo.2017.3924

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