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Location of NLS-RARα protein in NB4 cell and nude mice

In the majority of acute promyelocytic leukemia (APL) cases, translocons produce a promyelocytic leukemia protein-retinoic acid receptor α (PML-RARα) fusion gene. Studies have reported that neutrophil elastase (NE) cleaves bcr-1-derived PML-RAα in early myeloid cells, leaving only the nuclear locali...

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Detalles Bibliográficos
Autores principales: Wang, Hui, Yang, Rong, Zhong, Liang, Zhu, Xin-Yu, Ma, Peng-Peng, Yang, Xiao-Qun, Jiang, Kai-Ling, Liu, Bei-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403253/
https://www.ncbi.nlm.nih.gov/pubmed/28454360
http://dx.doi.org/10.3892/ol.2017.5706