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Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles

Numerous botanicals have been shown to exhibit in vitro and in vivo anticancer activity, some of which is the result of the induction of reactive oxygen species (ROS) in cancer cells with a high ROS content. The present study compared sensitivities to a series of botanicals among cancer cell lines,...

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Autores principales: Cohen, Zoya, Maimon, Yair, Samuels, Noah, Berger, Raanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403330/
https://www.ncbi.nlm.nih.gov/pubmed/28454445
http://dx.doi.org/10.3892/ol.2017.5747
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author Cohen, Zoya
Maimon, Yair
Samuels, Noah
Berger, Raanan
author_facet Cohen, Zoya
Maimon, Yair
Samuels, Noah
Berger, Raanan
author_sort Cohen, Zoya
collection PubMed
description Numerous botanicals have been shown to exhibit in vitro and in vivo anticancer activity, some of which is the result of the induction of reactive oxygen species (ROS) in cancer cells with a high ROS content. The present study compared sensitivities to a series of botanicals among cancer cell lines, using an XTT viability test, in order to create a specific cancer-herb profile. Of the 27 botanicals screened, 10 exhibited a cytotoxic effect, 7 of which were ROS-mediated. The sensitivity profiles of the ROS-inducing botanicals in 10 cancer cell lines were similar, unlike 3 cytotoxic ROS-independent botanicals that displayed divergent botanical-specific profiles. The correlation between sensitivity profiles of ROS-inducing botanicals suggests a common mechanism of action, in contrast to the varied mechanism of ROS-independent botanicals. This implies that the investigation of the anticancer activity of botanicals should start with the examination of ROS-mediated activity. Further investigation of ROS sensitivity among various tumor types is required in order to guide research into developing evidence-based guidelines in the use of botanicals for cancer treatment.
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spelling pubmed-54033302017-04-27 Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles Cohen, Zoya Maimon, Yair Samuels, Noah Berger, Raanan Oncol Lett Articles Numerous botanicals have been shown to exhibit in vitro and in vivo anticancer activity, some of which is the result of the induction of reactive oxygen species (ROS) in cancer cells with a high ROS content. The present study compared sensitivities to a series of botanicals among cancer cell lines, using an XTT viability test, in order to create a specific cancer-herb profile. Of the 27 botanicals screened, 10 exhibited a cytotoxic effect, 7 of which were ROS-mediated. The sensitivity profiles of the ROS-inducing botanicals in 10 cancer cell lines were similar, unlike 3 cytotoxic ROS-independent botanicals that displayed divergent botanical-specific profiles. The correlation between sensitivity profiles of ROS-inducing botanicals suggests a common mechanism of action, in contrast to the varied mechanism of ROS-independent botanicals. This implies that the investigation of the anticancer activity of botanicals should start with the examination of ROS-mediated activity. Further investigation of ROS sensitivity among various tumor types is required in order to guide research into developing evidence-based guidelines in the use of botanicals for cancer treatment. D.A. Spandidos 2017-04 2017-02-17 /pmc/articles/PMC5403330/ /pubmed/28454445 http://dx.doi.org/10.3892/ol.2017.5747 Text en Copyright: © Cohen et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Cohen, Zoya
Maimon, Yair
Samuels, Noah
Berger, Raanan
Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles
title Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles
title_full Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles
title_fullStr Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles
title_full_unstemmed Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles
title_short Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles
title_sort role of reactive oxygen species in the anticancer activity of botanicals: comparing sensitivity profiles
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403330/
https://www.ncbi.nlm.nih.gov/pubmed/28454445
http://dx.doi.org/10.3892/ol.2017.5747
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