FFJ-3 inhibits PKM2 protein expression via the PI3K/Akt signaling pathway and activates the mitochondrial apoptosis signaling pathway in human cancer cells

Pyruvate kinase isoenzyme M2 (PKM2) has previously been identified as a tumor biomarker and potential therapeutic target for the treatment of cancer. In the present study, FFJ-3, a structurally modified version of mollugin, an extract of the Traditional Chinese herbal medicine Rubia tinctorum (madde...

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Detalles Bibliográficos
Autores principales: Li, Dengyun, Wei, Xiaoli, Ma, Mingming, Jia, Huina, Zhang, Yu, Kang, Wenyi, Wang, Tianxiao, Shi, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403336/
https://www.ncbi.nlm.nih.gov/pubmed/28454440
http://dx.doi.org/10.3892/ol.2017.5761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403336/
https://www.ncbi.nlm.nih.gov/pubmed/28454440
http://dx.doi.org/10.3892/ol.2017.5761

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