Cargando…

Effects of the modified electric convulsive treatment (MECT) on cell factors of schizophrenia

The expression of cell factors of schizophrenia and the effect of the modified electric convulsive treatment (MECT) were studied. In total, 156 patients with schizophrenia were selected, and divided into the drug group (70 cases) and the drug combined with MECT group (combined group) (86 cases) acco...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Yong-Fang, Fu, Hua-Bin, Liu, Zhi-Yuan, Lu, Wei, Luo, Ke-Yong, Zhu, Hong-Ri, Ning, Wei-Dong, Chen, Feng, Yang, Li-Yu, Zhou, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403391/
https://www.ncbi.nlm.nih.gov/pubmed/28450912
http://dx.doi.org/10.3892/etm.2017.4075
_version_ 1783231412248248320
author Guo, Yong-Fang
Fu, Hua-Bin
Liu, Zhi-Yuan
Lu, Wei
Luo, Ke-Yong
Zhu, Hong-Ri
Ning, Wei-Dong
Chen, Feng
Yang, Li-Yu
Zhou, Xiao-Dong
author_facet Guo, Yong-Fang
Fu, Hua-Bin
Liu, Zhi-Yuan
Lu, Wei
Luo, Ke-Yong
Zhu, Hong-Ri
Ning, Wei-Dong
Chen, Feng
Yang, Li-Yu
Zhou, Xiao-Dong
author_sort Guo, Yong-Fang
collection PubMed
description The expression of cell factors of schizophrenia and the effect of the modified electric convulsive treatment (MECT) were studied. In total, 156 patients with schizophrenia were selected, and divided into the drug group (70 cases) and the drug combined with MECT group (combined group) (86 cases) according to the treatment methods. In addition, 70 cases of healthy volunteers (control group) were selected according to the closest matching method based on 1:1 of age and gender. The drug treatment, consisted of anti-psychotic drugs, such as risperidone 2–8, quetiapine 300–750, ziprasidone 80–160 or aripiprazole 10–30 mg/day, and for the control group, we used the electric spasm therapeutic instrument, Thymatron(®)IV Systems up to 6 times, 3 times a week. The levels of interleukin (IL)-10, IL-4, IL-6 and IL-1 were detected before and after treatment by ELISA. The positive and negative symptom scale (PANSS) was used to evaluate the efficiency. Before the treatment, IL-1 and IL-6 levels of drug and combined groups were significantly higher than those of the control group (P<0.05), while IL-4 and IL-10 had no difference with the control group. There was no significant difference of each factor between the drug and combined groups. After treatment, IL-1, IL-6 and IL-10 of the drug group did not change compared to the levels before treatment, but IL-4 increased significantly; IL-1 and IL-10 of the combined group did not change, while IL-4 and IL-6 increased significantly; IL-1, IL-4 and IL-6 of the drug and combined groups were significantly (P<0.05) higher than those in the control group, but not IL-10. IL-1, IL-4 and IL-6 levels of the combined group were significantly higher (P<0.05) than those of the drug group. After treatment, the PANSS scores of the two groups decreased and the combined group decreased more significantly (P<0.05). The reduction rate of the combined group was significantly higher (P<0.05) than that of the drug group. The total efficiency of the combined group was significantly higher than that of the drug group, and after comparing these levels, there was statistical significance (P<0.05). IL-1, IL-4, IL-6 and IL-10 levels of the drug and combined groups before treatment were not associated with PANSS scores and the variation of IL-1, IL-4, IL-6 and IL-10 of the drug and combined groups had no correlation with the reduction rate of the PANSS. The results showed that, cell factors of schizophrenia had an abnormal expression, and medication and MECT can affect the expression level. In addition, MECT can improve the effect in the treatment of schizophrenia, but had no obvious correlation with the change of cell factors.
format Online
Article
Text
id pubmed-5403391
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-54033912017-04-27 Effects of the modified electric convulsive treatment (MECT) on cell factors of schizophrenia Guo, Yong-Fang Fu, Hua-Bin Liu, Zhi-Yuan Lu, Wei Luo, Ke-Yong Zhu, Hong-Ri Ning, Wei-Dong Chen, Feng Yang, Li-Yu Zhou, Xiao-Dong Exp Ther Med Articles The expression of cell factors of schizophrenia and the effect of the modified electric convulsive treatment (MECT) were studied. In total, 156 patients with schizophrenia were selected, and divided into the drug group (70 cases) and the drug combined with MECT group (combined group) (86 cases) according to the treatment methods. In addition, 70 cases of healthy volunteers (control group) were selected according to the closest matching method based on 1:1 of age and gender. The drug treatment, consisted of anti-psychotic drugs, such as risperidone 2–8, quetiapine 300–750, ziprasidone 80–160 or aripiprazole 10–30 mg/day, and for the control group, we used the electric spasm therapeutic instrument, Thymatron(®)IV Systems up to 6 times, 3 times a week. The levels of interleukin (IL)-10, IL-4, IL-6 and IL-1 were detected before and after treatment by ELISA. The positive and negative symptom scale (PANSS) was used to evaluate the efficiency. Before the treatment, IL-1 and IL-6 levels of drug and combined groups were significantly higher than those of the control group (P<0.05), while IL-4 and IL-10 had no difference with the control group. There was no significant difference of each factor between the drug and combined groups. After treatment, IL-1, IL-6 and IL-10 of the drug group did not change compared to the levels before treatment, but IL-4 increased significantly; IL-1 and IL-10 of the combined group did not change, while IL-4 and IL-6 increased significantly; IL-1, IL-4 and IL-6 of the drug and combined groups were significantly (P<0.05) higher than those in the control group, but not IL-10. IL-1, IL-4 and IL-6 levels of the combined group were significantly higher (P<0.05) than those of the drug group. After treatment, the PANSS scores of the two groups decreased and the combined group decreased more significantly (P<0.05). The reduction rate of the combined group was significantly higher (P<0.05) than that of the drug group. The total efficiency of the combined group was significantly higher than that of the drug group, and after comparing these levels, there was statistical significance (P<0.05). IL-1, IL-4, IL-6 and IL-10 levels of the drug and combined groups before treatment were not associated with PANSS scores and the variation of IL-1, IL-4, IL-6 and IL-10 of the drug and combined groups had no correlation with the reduction rate of the PANSS. The results showed that, cell factors of schizophrenia had an abnormal expression, and medication and MECT can affect the expression level. In addition, MECT can improve the effect in the treatment of schizophrenia, but had no obvious correlation with the change of cell factors. D.A. Spandidos 2017-03 2017-01-20 /pmc/articles/PMC5403391/ /pubmed/28450912 http://dx.doi.org/10.3892/etm.2017.4075 Text en Copyright: © Guo et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Guo, Yong-Fang
Fu, Hua-Bin
Liu, Zhi-Yuan
Lu, Wei
Luo, Ke-Yong
Zhu, Hong-Ri
Ning, Wei-Dong
Chen, Feng
Yang, Li-Yu
Zhou, Xiao-Dong
Effects of the modified electric convulsive treatment (MECT) on cell factors of schizophrenia
title Effects of the modified electric convulsive treatment (MECT) on cell factors of schizophrenia
title_full Effects of the modified electric convulsive treatment (MECT) on cell factors of schizophrenia
title_fullStr Effects of the modified electric convulsive treatment (MECT) on cell factors of schizophrenia
title_full_unstemmed Effects of the modified electric convulsive treatment (MECT) on cell factors of schizophrenia
title_short Effects of the modified electric convulsive treatment (MECT) on cell factors of schizophrenia
title_sort effects of the modified electric convulsive treatment (mect) on cell factors of schizophrenia
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403391/
https://www.ncbi.nlm.nih.gov/pubmed/28450912
http://dx.doi.org/10.3892/etm.2017.4075
work_keys_str_mv AT guoyongfang effectsofthemodifiedelectricconvulsivetreatmentmectoncellfactorsofschizophrenia
AT fuhuabin effectsofthemodifiedelectricconvulsivetreatmentmectoncellfactorsofschizophrenia
AT liuzhiyuan effectsofthemodifiedelectricconvulsivetreatmentmectoncellfactorsofschizophrenia
AT luwei effectsofthemodifiedelectricconvulsivetreatmentmectoncellfactorsofschizophrenia
AT luokeyong effectsofthemodifiedelectricconvulsivetreatmentmectoncellfactorsofschizophrenia
AT zhuhongri effectsofthemodifiedelectricconvulsivetreatmentmectoncellfactorsofschizophrenia
AT ningweidong effectsofthemodifiedelectricconvulsivetreatmentmectoncellfactorsofschizophrenia
AT chenfeng effectsofthemodifiedelectricconvulsivetreatmentmectoncellfactorsofschizophrenia
AT yangliyu effectsofthemodifiedelectricconvulsivetreatmentmectoncellfactorsofschizophrenia
AT zhouxiaodong effectsofthemodifiedelectricconvulsivetreatmentmectoncellfactorsofschizophrenia