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Anaplastic astrocytoma cells not detectable on autopsy following long-term temozolomide treatment: A case report
We herein present an autopsy case of a glioma patient who received long-term treatment with temozolomide (TMZ). The patient, a 35-year-old man with a hypointense tumor of the left frontal lobe, without contrast enhancement following gadolinium (Gd) administration on T1-weighted images, underwent tum...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403526/ https://www.ncbi.nlm.nih.gov/pubmed/28451406 http://dx.doi.org/10.3892/mco.2017.1160 |
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author | Hirano, Hirofumi Kawahara, Takashi Niiro, Masaki Yonezawa, Hajime Takajyou, Tomoko Ohi, Yasuyo Kitazono, Ikumi Sakae, Kiyohiro Arita, Kazunori |
author_facet | Hirano, Hirofumi Kawahara, Takashi Niiro, Masaki Yonezawa, Hajime Takajyou, Tomoko Ohi, Yasuyo Kitazono, Ikumi Sakae, Kiyohiro Arita, Kazunori |
author_sort | Hirano, Hirofumi |
collection | PubMed |
description | We herein present an autopsy case of a glioma patient who received long-term treatment with temozolomide (TMZ). The patient, a 35-year-old man with a hypointense tumor of the left frontal lobe, without contrast enhancement following gadolinium (Gd) administration on T1-weighted images, underwent tumor removal surgery, after which the tumor was diagnosed as anaplastic astrocytoma. By the third round of surgery, the tumor had progressed to anaplastic astrocytoma with contrast enhancement following Gd administration, and the patient received 60 Gy of external beam radiotherapy and nimustine hydrochloride (ACNU)-based chemotherapy. After the fifth tumor removal surgery, TMZ was substituted with ACNU chemotherapy, which suppressed tumor progression. Following the 41st TMZ treatment, hemorrhage was observed in the residual tumor, and the hematoma had been replaced by a hemangioma. The hemangioma and surrounding brain tissue was removed during the sixth surgery. The patient survived for 14 years and 9 months after the initial surgery, but succumbed to hydrocephalus due to bleeding from hemangiomas. The histopathological specimens of the first to the sixth surgeries revealed mutant isocitrate dehydrogenase 1 (IDH1; R132H point mutation) and p53-positive tumor cells, but cells positive for the R132H mutation or p53 could not be detected by immunohistochemistry in the autopsy specimens of the brain after 108 courses of TMZ treatment. Mutant IDH1 (R132H) cells were also not detected in the autopsy specimens of the brain by polymerase chain reaction analysis. |
format | Online Article Text |
id | pubmed-5403526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-54035262017-04-27 Anaplastic astrocytoma cells not detectable on autopsy following long-term temozolomide treatment: A case report Hirano, Hirofumi Kawahara, Takashi Niiro, Masaki Yonezawa, Hajime Takajyou, Tomoko Ohi, Yasuyo Kitazono, Ikumi Sakae, Kiyohiro Arita, Kazunori Mol Clin Oncol Articles We herein present an autopsy case of a glioma patient who received long-term treatment with temozolomide (TMZ). The patient, a 35-year-old man with a hypointense tumor of the left frontal lobe, without contrast enhancement following gadolinium (Gd) administration on T1-weighted images, underwent tumor removal surgery, after which the tumor was diagnosed as anaplastic astrocytoma. By the third round of surgery, the tumor had progressed to anaplastic astrocytoma with contrast enhancement following Gd administration, and the patient received 60 Gy of external beam radiotherapy and nimustine hydrochloride (ACNU)-based chemotherapy. After the fifth tumor removal surgery, TMZ was substituted with ACNU chemotherapy, which suppressed tumor progression. Following the 41st TMZ treatment, hemorrhage was observed in the residual tumor, and the hematoma had been replaced by a hemangioma. The hemangioma and surrounding brain tissue was removed during the sixth surgery. The patient survived for 14 years and 9 months after the initial surgery, but succumbed to hydrocephalus due to bleeding from hemangiomas. The histopathological specimens of the first to the sixth surgeries revealed mutant isocitrate dehydrogenase 1 (IDH1; R132H point mutation) and p53-positive tumor cells, but cells positive for the R132H mutation or p53 could not be detected by immunohistochemistry in the autopsy specimens of the brain after 108 courses of TMZ treatment. Mutant IDH1 (R132H) cells were also not detected in the autopsy specimens of the brain by polymerase chain reaction analysis. D.A. Spandidos 2017-03 2017-02-07 /pmc/articles/PMC5403526/ /pubmed/28451406 http://dx.doi.org/10.3892/mco.2017.1160 Text en Copyright: © Hirano et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Hirano, Hirofumi Kawahara, Takashi Niiro, Masaki Yonezawa, Hajime Takajyou, Tomoko Ohi, Yasuyo Kitazono, Ikumi Sakae, Kiyohiro Arita, Kazunori Anaplastic astrocytoma cells not detectable on autopsy following long-term temozolomide treatment: A case report |
title | Anaplastic astrocytoma cells not detectable on autopsy following long-term temozolomide treatment: A case report |
title_full | Anaplastic astrocytoma cells not detectable on autopsy following long-term temozolomide treatment: A case report |
title_fullStr | Anaplastic astrocytoma cells not detectable on autopsy following long-term temozolomide treatment: A case report |
title_full_unstemmed | Anaplastic astrocytoma cells not detectable on autopsy following long-term temozolomide treatment: A case report |
title_short | Anaplastic astrocytoma cells not detectable on autopsy following long-term temozolomide treatment: A case report |
title_sort | anaplastic astrocytoma cells not detectable on autopsy following long-term temozolomide treatment: a case report |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403526/ https://www.ncbi.nlm.nih.gov/pubmed/28451406 http://dx.doi.org/10.3892/mco.2017.1160 |
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