Cargando…
Polycomb group expression signatures in the malignant progression of gliomas
Polycomb group (PcG) proteins form at least two key complexes, namely polycomb repressive complex 1 and polycomb repressive complex 2. These complexes are involved in the progression of various cancers. Systematic research has not been conducted on the aberrant expression of PcG members in gliomas....
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403712/ https://www.ncbi.nlm.nih.gov/pubmed/28454437 http://dx.doi.org/10.3892/ol.2017.5753 |
_version_ | 1783231441781391360 |
---|---|
author | Hu, Qi Wu, Weining Zeng, Ailiang Yu, Tianfu Shen, Feng Nie, Er Wang, Yingyi Liu, Ning Zhang, Junxia You, Yongping |
author_facet | Hu, Qi Wu, Weining Zeng, Ailiang Yu, Tianfu Shen, Feng Nie, Er Wang, Yingyi Liu, Ning Zhang, Junxia You, Yongping |
author_sort | Hu, Qi |
collection | PubMed |
description | Polycomb group (PcG) proteins form at least two key complexes, namely polycomb repressive complex 1 and polycomb repressive complex 2. These complexes are involved in the progression of various cancers. Systematic research has not been conducted on the aberrant expression of PcG members in gliomas. Using the Chinese Glioma Genome Atlas data set, PcG expression patterns between normal brain tissues and glioma samples were analyzed, and a PcG-based classifier was then developed using BRB Cox regression and risk-score model. These results were validated in an independent GSE16011 set. A total of six PcGs [chromobox protein homolog (CBX) 6, CBX7, PHD finger protein 1, enhancer of zeste homolog 2 (EZH2), DNA (cytosine-5-)-methyltransferase 3β (DNMT3B) and polyhomeotic-like protein 2] were identified to be associated with glioma grade. Survival analysis then revealed a five-PcG gene signature one protective gene (enhancer of zeste homolog 1) and four risky genes (EZH2, PHD finger protein 19, DNMT3A and DNMT3B), which may identify patients with high risk of poor prognosis of glioma. Multivariate Cox analysis indicated that the five-PcG signature was an independent prognostic biomarker. These findings indicated that a novel prognostic classifier, five-PcG signature, served as an independent prognostic marker for patients with glioma. |
format | Online Article Text |
id | pubmed-5403712 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-54037122017-04-27 Polycomb group expression signatures in the malignant progression of gliomas Hu, Qi Wu, Weining Zeng, Ailiang Yu, Tianfu Shen, Feng Nie, Er Wang, Yingyi Liu, Ning Zhang, Junxia You, Yongping Oncol Lett Articles Polycomb group (PcG) proteins form at least two key complexes, namely polycomb repressive complex 1 and polycomb repressive complex 2. These complexes are involved in the progression of various cancers. Systematic research has not been conducted on the aberrant expression of PcG members in gliomas. Using the Chinese Glioma Genome Atlas data set, PcG expression patterns between normal brain tissues and glioma samples were analyzed, and a PcG-based classifier was then developed using BRB Cox regression and risk-score model. These results were validated in an independent GSE16011 set. A total of six PcGs [chromobox protein homolog (CBX) 6, CBX7, PHD finger protein 1, enhancer of zeste homolog 2 (EZH2), DNA (cytosine-5-)-methyltransferase 3β (DNMT3B) and polyhomeotic-like protein 2] were identified to be associated with glioma grade. Survival analysis then revealed a five-PcG gene signature one protective gene (enhancer of zeste homolog 1) and four risky genes (EZH2, PHD finger protein 19, DNMT3A and DNMT3B), which may identify patients with high risk of poor prognosis of glioma. Multivariate Cox analysis indicated that the five-PcG signature was an independent prognostic biomarker. These findings indicated that a novel prognostic classifier, five-PcG signature, served as an independent prognostic marker for patients with glioma. D.A. Spandidos 2017-04 2017-02-20 /pmc/articles/PMC5403712/ /pubmed/28454437 http://dx.doi.org/10.3892/ol.2017.5753 Text en Copyright: © Hu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Hu, Qi Wu, Weining Zeng, Ailiang Yu, Tianfu Shen, Feng Nie, Er Wang, Yingyi Liu, Ning Zhang, Junxia You, Yongping Polycomb group expression signatures in the malignant progression of gliomas |
title | Polycomb group expression signatures in the malignant progression of gliomas |
title_full | Polycomb group expression signatures in the malignant progression of gliomas |
title_fullStr | Polycomb group expression signatures in the malignant progression of gliomas |
title_full_unstemmed | Polycomb group expression signatures in the malignant progression of gliomas |
title_short | Polycomb group expression signatures in the malignant progression of gliomas |
title_sort | polycomb group expression signatures in the malignant progression of gliomas |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403712/ https://www.ncbi.nlm.nih.gov/pubmed/28454437 http://dx.doi.org/10.3892/ol.2017.5753 |
work_keys_str_mv | AT huqi polycombgroupexpressionsignaturesinthemalignantprogressionofgliomas AT wuweining polycombgroupexpressionsignaturesinthemalignantprogressionofgliomas AT zengailiang polycombgroupexpressionsignaturesinthemalignantprogressionofgliomas AT yutianfu polycombgroupexpressionsignaturesinthemalignantprogressionofgliomas AT shenfeng polycombgroupexpressionsignaturesinthemalignantprogressionofgliomas AT nieer polycombgroupexpressionsignaturesinthemalignantprogressionofgliomas AT wangyingyi polycombgroupexpressionsignaturesinthemalignantprogressionofgliomas AT liuning polycombgroupexpressionsignaturesinthemalignantprogressionofgliomas AT zhangjunxia polycombgroupexpressionsignaturesinthemalignantprogressionofgliomas AT youyongping polycombgroupexpressionsignaturesinthemalignantprogressionofgliomas |