Quantitative analysis of amphiphilic N-alkyloxypyridinecarboximidamide by liquid chromatography–tandem mass spectrometry

LC–MS/MS method to determine hydrophobic N-alkyloxy substituted amidines: N-(2-ethylhexyloxy)pyridine-2-carboximidamide, N-(2-ethylhexyloxy)pyridine-3-carboximidamide, N-(2-ethylhexyloxy)pyridine-4-carboximidamide, N-decyloxy pyridine-2-carboximidamide, N-decyloxypyridine-3-carboximidamide and N-dec...

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Autores principales: Wojciechowska, Irmina, Wojciechowska, Aleksandra, Wieszczycka, Karolina, Aksamitowski, Przemysław, Zembrzuska, Joanna, Framski, Grzegorz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403844/
https://www.ncbi.nlm.nih.gov/pubmed/28496290
http://dx.doi.org/10.1007/s11696-016-0019-1
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author Wojciechowska, Irmina
Wojciechowska, Aleksandra
Wieszczycka, Karolina
Aksamitowski, Przemysław
Zembrzuska, Joanna
Framski, Grzegorz
author_facet Wojciechowska, Irmina
Wojciechowska, Aleksandra
Wieszczycka, Karolina
Aksamitowski, Przemysław
Zembrzuska, Joanna
Framski, Grzegorz
author_sort Wojciechowska, Irmina
collection PubMed
description LC–MS/MS method to determine hydrophobic N-alkyloxy substituted amidines: N-(2-ethylhexyloxy)pyridine-2-carboximidamide, N-(2-ethylhexyloxy)pyridine-3-carboximidamide, N-(2-ethylhexyloxy)pyridine-4-carboximidamide, N-decyloxy pyridine-2-carboximidamide, N-decyloxypyridine-3-carboximidamide and N-decyloxypyridine-4-carboximidamide was developed and validated in terms of linearity, precision and accuracy. The developed method was successfully applied to monitor and control the synthesis process. The experimental data points indicated that the straight chain alkyl bromide reacted most rapidly than branched alkyl bromide and the enhancement of the reaction efficiency strongly depended on reaction temperature.
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spelling pubmed-54038442017-05-09 Quantitative analysis of amphiphilic N-alkyloxypyridinecarboximidamide by liquid chromatography–tandem mass spectrometry Wojciechowska, Irmina Wojciechowska, Aleksandra Wieszczycka, Karolina Aksamitowski, Przemysław Zembrzuska, Joanna Framski, Grzegorz Chem. Zvesti Original Paper LC–MS/MS method to determine hydrophobic N-alkyloxy substituted amidines: N-(2-ethylhexyloxy)pyridine-2-carboximidamide, N-(2-ethylhexyloxy)pyridine-3-carboximidamide, N-(2-ethylhexyloxy)pyridine-4-carboximidamide, N-decyloxy pyridine-2-carboximidamide, N-decyloxypyridine-3-carboximidamide and N-decyloxypyridine-4-carboximidamide was developed and validated in terms of linearity, precision and accuracy. The developed method was successfully applied to monitor and control the synthesis process. The experimental data points indicated that the straight chain alkyl bromide reacted most rapidly than branched alkyl bromide and the enhancement of the reaction efficiency strongly depended on reaction temperature. Springer International Publishing 2016-12-10 2017 /pmc/articles/PMC5403844/ /pubmed/28496290 http://dx.doi.org/10.1007/s11696-016-0019-1 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Paper
Wojciechowska, Irmina
Wojciechowska, Aleksandra
Wieszczycka, Karolina
Aksamitowski, Przemysław
Zembrzuska, Joanna
Framski, Grzegorz
Quantitative analysis of amphiphilic N-alkyloxypyridinecarboximidamide by liquid chromatography–tandem mass spectrometry
title Quantitative analysis of amphiphilic N-alkyloxypyridinecarboximidamide by liquid chromatography–tandem mass spectrometry
title_full Quantitative analysis of amphiphilic N-alkyloxypyridinecarboximidamide by liquid chromatography–tandem mass spectrometry
title_fullStr Quantitative analysis of amphiphilic N-alkyloxypyridinecarboximidamide by liquid chromatography–tandem mass spectrometry
title_full_unstemmed Quantitative analysis of amphiphilic N-alkyloxypyridinecarboximidamide by liquid chromatography–tandem mass spectrometry
title_short Quantitative analysis of amphiphilic N-alkyloxypyridinecarboximidamide by liquid chromatography–tandem mass spectrometry
title_sort quantitative analysis of amphiphilic n-alkyloxypyridinecarboximidamide by liquid chromatography–tandem mass spectrometry
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403844/
https://www.ncbi.nlm.nih.gov/pubmed/28496290
http://dx.doi.org/10.1007/s11696-016-0019-1
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