Comparative plasma and tissue distribution of Sun Pharma’s generic doxorubicin HCl liposome injection versus Caelyx(®) (doxorubicin HCl liposome injection) in syngeneic fibrosarcoma-bearing BALB/c mice and Sprague–Dawley rats

PURPOSE: The liposomal formulation of doxorubicin [doxorubicin (DXR) hydrochloride (HCl) liposome injection, Caelyx(®)] alters the tissue distribution of DXR as compared with nonliposomal DXR, resulting in an improved benefit-risk profile. We conducted studies in murine models to compare the plasma...

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Detalles Bibliográficos
Autores principales: Burade, Vinod, Bhowmick, Subhas, Maiti, Kuntal, Zalawadia, Rishit, Jain, Deepak, Rajamannar, Thennati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403873/
https://www.ncbi.nlm.nih.gov/pubmed/28349166
http://dx.doi.org/10.1007/s00280-017-3278-9

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