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PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis

OBJECTIVE: In the hypothalamic arcuate nucleus (ARC), orexigenic agouti-related peptide (AgRP) neurons regulate feeding behavior and energy homeostasis, functions connected to bone metabolism. The 3-phosphoinositide-dependent protein kinase-1 (PDK1) serves as a major signaling molecule particularly...

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Detalles Bibliográficos
Autores principales:	Sasanuma, Hideyuki, Nakata, Masanori, Parmila, Kumari, Nakae, Jun, Yada, Toshihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404105/ https://www.ncbi.nlm.nih.gov/pubmed/28462077 http://dx.doi.org/10.1016/j.molmet.2017.02.003

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