Cargando…

Considerations for the rational design of a Chlamydia vaccine

Chlamydia trachomatis is the leading cause of preventable blindness and the most common bacterial sexually transmitted infection. Remarkable progress in vaccine research over the past six decades has led to the advancement of novel C. trachomatis vaccine candidates into clinical trials. However, man...

Descripción completa

Detalles Bibliográficos
Autores principales: Liang, Steven, Bulir, David, Kaushic, Charu, Mahony, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404357/
https://www.ncbi.nlm.nih.gov/pubmed/27835064
http://dx.doi.org/10.1080/21645515.2016.1252886
_version_ 1783231584855392256
author Liang, Steven
Bulir, David
Kaushic, Charu
Mahony, James
author_facet Liang, Steven
Bulir, David
Kaushic, Charu
Mahony, James
author_sort Liang, Steven
collection PubMed
description Chlamydia trachomatis is the leading cause of preventable blindness and the most common bacterial sexually transmitted infection. Remarkable progress in vaccine research over the past six decades has led to the advancement of novel C. trachomatis vaccine candidates into clinical trials. However, many questions regarding the role of specific cellular populations and molecular mechanisms in protective immunity against human C. trachomatis genital tract infections remain unanswered. Biomarkers of vaccine induced protective immunity are elusive in humans, while a cautionary message on the translatability of data obtained from current animal models has emanated from vaccine research and development efforts against other important human pathogens. In this commentary, we highlight recent advances in Chlamydia vaccine development and discuss their implications in the context of a rational approach to the design of a human C. trachomatis vaccine.
format Online
Article
Text
id pubmed-5404357
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-54043572017-05-03 Considerations for the rational design of a Chlamydia vaccine Liang, Steven Bulir, David Kaushic, Charu Mahony, James Hum Vaccin Immunother Commentary Chlamydia trachomatis is the leading cause of preventable blindness and the most common bacterial sexually transmitted infection. Remarkable progress in vaccine research over the past six decades has led to the advancement of novel C. trachomatis vaccine candidates into clinical trials. However, many questions regarding the role of specific cellular populations and molecular mechanisms in protective immunity against human C. trachomatis genital tract infections remain unanswered. Biomarkers of vaccine induced protective immunity are elusive in humans, while a cautionary message on the translatability of data obtained from current animal models has emanated from vaccine research and development efforts against other important human pathogens. In this commentary, we highlight recent advances in Chlamydia vaccine development and discuss their implications in the context of a rational approach to the design of a human C. trachomatis vaccine. Taylor & Francis 2016-11-11 /pmc/articles/PMC5404357/ /pubmed/27835064 http://dx.doi.org/10.1080/21645515.2016.1252886 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Commentary
Liang, Steven
Bulir, David
Kaushic, Charu
Mahony, James
Considerations for the rational design of a Chlamydia vaccine
title Considerations for the rational design of a Chlamydia vaccine
title_full Considerations for the rational design of a Chlamydia vaccine
title_fullStr Considerations for the rational design of a Chlamydia vaccine
title_full_unstemmed Considerations for the rational design of a Chlamydia vaccine
title_short Considerations for the rational design of a Chlamydia vaccine
title_sort considerations for the rational design of a chlamydia vaccine
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404357/
https://www.ncbi.nlm.nih.gov/pubmed/27835064
http://dx.doi.org/10.1080/21645515.2016.1252886
work_keys_str_mv AT liangsteven considerationsfortherationaldesignofachlamydiavaccine
AT bulirdavid considerationsfortherationaldesignofachlamydiavaccine
AT kaushiccharu considerationsfortherationaldesignofachlamydiavaccine
AT mahonyjames considerationsfortherationaldesignofachlamydiavaccine