De novo disruption of promoter and exon 1 of STAR gene reveals essential role for gonadal development

SUMMARY: Cholesterol transport into the mitochondria is required for synthesis of the first steroid, pregnenolone. Cholesterol is transported by the steroidogenic acute regulatory protein (STAR), which acts at the outer mitochondrial membrane prior to its import. Mutations in the STAR protein result...

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Detalles Bibliográficos
Autores principales: Piya, Anil, Kaur, Jasmeet, Rice, Alan M, Bose, Himangshu S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2017
Materias:
Insight into Disease Pathogenesis or Mechanism of Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404458/
https://www.ncbi.nlm.nih.gov/pubmed/28458886
http://dx.doi.org/10.1530/EDM-16-0120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404458/
https://www.ncbi.nlm.nih.gov/pubmed/28458886
http://dx.doi.org/10.1530/EDM-16-0120

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