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Estimating the annual burden of tick-borne encephalitis to inform vaccination policy, Slovenia, 2009 to 2013

With an annual incidence between 8 and 15 per 100,000 population in the period from 2009 to 2013, Slovenia has one of the highest notified incidences of tick-borne encephalitis (TBE) in Europe. TBE vaccination coverage remains at about 7.3%. To inform vaccination policy, we used surveillance data fr...

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Autores principales: Fafangel, Mario, Cassini, Alessandro, Colzani, Edoardo, Klavs, Irena, Grgič Vitek, Marta, Učakar, Veronika, Muehlen, Marion, Vudrag, Marko, Kraigher, Alenka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404479/
https://www.ncbi.nlm.nih.gov/pubmed/28449731
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.16.30509
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author Fafangel, Mario
Cassini, Alessandro
Colzani, Edoardo
Klavs, Irena
Grgič Vitek, Marta
Učakar, Veronika
Muehlen, Marion
Vudrag, Marko
Kraigher, Alenka
author_facet Fafangel, Mario
Cassini, Alessandro
Colzani, Edoardo
Klavs, Irena
Grgič Vitek, Marta
Učakar, Veronika
Muehlen, Marion
Vudrag, Marko
Kraigher, Alenka
author_sort Fafangel, Mario
collection PubMed
description With an annual incidence between 8 and 15 per 100,000 population in the period from 2009 to 2013, Slovenia has one of the highest notified incidences of tick-borne encephalitis (TBE) in Europe. TBE vaccination coverage remains at about 7.3%. To inform vaccination policy, we used surveillance data from 2009 to 2013 to calculate the overall and age- and sex-specific mean annual TBE incidence. We estimated disability-adjusted life years (DALYs) with 95% uncertainty intervals (UI), using the Burden of Communicable Diseases in Europe approach from the European Centre for Disease Prevention and Control. The mean annual incidence was 11.6 per 100,000 population, peaking in older age groups (50–74 years: 18.5/100,000) while relatively lower among children (5–14 years: 10.2/100,000). We estimated an overall 10.95 DALYs per 100,000 population per year (95% UI: 10.25-11.65). In contrast to the TBE incidence, the disease burden in children aged 5–14 years was higher than in adults aged 50–74 years: 17.31 (95% UI: 14.58–20.08) and 11.58 (95% UI: 10.25–12.91) DALYs per 100,000 stratum-specific population, respectively. In a limited resource setting where prioritisation of TBE vaccination strategies is required, vaccination programmes targeting children may have a higher impact on disease burden.
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spelling pubmed-54044792017-05-15 Estimating the annual burden of tick-borne encephalitis to inform vaccination policy, Slovenia, 2009 to 2013 Fafangel, Mario Cassini, Alessandro Colzani, Edoardo Klavs, Irena Grgič Vitek, Marta Učakar, Veronika Muehlen, Marion Vudrag, Marko Kraigher, Alenka Euro Surveill Research Article With an annual incidence between 8 and 15 per 100,000 population in the period from 2009 to 2013, Slovenia has one of the highest notified incidences of tick-borne encephalitis (TBE) in Europe. TBE vaccination coverage remains at about 7.3%. To inform vaccination policy, we used surveillance data from 2009 to 2013 to calculate the overall and age- and sex-specific mean annual TBE incidence. We estimated disability-adjusted life years (DALYs) with 95% uncertainty intervals (UI), using the Burden of Communicable Diseases in Europe approach from the European Centre for Disease Prevention and Control. The mean annual incidence was 11.6 per 100,000 population, peaking in older age groups (50–74 years: 18.5/100,000) while relatively lower among children (5–14 years: 10.2/100,000). We estimated an overall 10.95 DALYs per 100,000 population per year (95% UI: 10.25-11.65). In contrast to the TBE incidence, the disease burden in children aged 5–14 years was higher than in adults aged 50–74 years: 17.31 (95% UI: 14.58–20.08) and 11.58 (95% UI: 10.25–12.91) DALYs per 100,000 stratum-specific population, respectively. In a limited resource setting where prioritisation of TBE vaccination strategies is required, vaccination programmes targeting children may have a higher impact on disease burden. European Centre for Disease Prevention and Control (ECDC) 2017-04-20 /pmc/articles/PMC5404479/ /pubmed/28449731 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.16.30509 Text en This article is copyright of The Authors, 2017. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Research Article
Fafangel, Mario
Cassini, Alessandro
Colzani, Edoardo
Klavs, Irena
Grgič Vitek, Marta
Učakar, Veronika
Muehlen, Marion
Vudrag, Marko
Kraigher, Alenka
Estimating the annual burden of tick-borne encephalitis to inform vaccination policy, Slovenia, 2009 to 2013
title Estimating the annual burden of tick-borne encephalitis to inform vaccination policy, Slovenia, 2009 to 2013
title_full Estimating the annual burden of tick-borne encephalitis to inform vaccination policy, Slovenia, 2009 to 2013
title_fullStr Estimating the annual burden of tick-borne encephalitis to inform vaccination policy, Slovenia, 2009 to 2013
title_full_unstemmed Estimating the annual burden of tick-borne encephalitis to inform vaccination policy, Slovenia, 2009 to 2013
title_short Estimating the annual burden of tick-borne encephalitis to inform vaccination policy, Slovenia, 2009 to 2013
title_sort estimating the annual burden of tick-borne encephalitis to inform vaccination policy, slovenia, 2009 to 2013
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404479/
https://www.ncbi.nlm.nih.gov/pubmed/28449731
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.16.30509
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